Anticoagulant

Savaysa® (Edoxaban) New Drug Evaluation Manufacturer: Daiichi Sankyo Drug Class: Anticoagulant (Factor Xa Inhibitor) Pharmacology: Edoxaban is a selective inhibitor of factor Xa, which inhibits prothrombinase activity to result in prevention of the conversion of prothrombin to thrombin, inhibition of subsequent thrombin-induced platelet aggregation, and suppression of resultant thrombus formation. Pharmacokinetics: Edoxaban has a half-life of 10 to 14 hours, a time to peak of 1 to 2 hours, a mean absolute bioavailability of 62%, and a volume of distribution of 107 liters. It undergoes moderate protein binding (approximately 55%) and is minimally metabolized (less than 10%) via hydrolysis and CYP3A4 conjugation and oxidation. The parent drug and predominant metabolite (M-4) are both excreted in the urine, with a clearance approximately 50% that of total body clearance. Clinical Trials: ENGAGE AF-TIMI 48 ClincalTrials.gov Identifier: NCT00781391 Effective aNticoaGulation with factor xA next GEneration in Atrial Fibrillation-Thrombolysis In Myocardial Infarction study 48 This Phase 3 clinical…

Venous thromboembolism, encompassing deep vein thrombosis and pulmonary embolism, has been increased in cancer patients, adversely affecting their prognosis. Low-molecular-weight heparins are recommended as efficacious and safe anticoagulation treatment in cancer patients. However, in clinical practice, oncologists prefer oral anticoagulation, especially if long-term or extended treatment is necessary. The novel oral anticoagulants have recently emerged as an alternative to the standard therapy…

Discussion EDTA entails the anticoagulant that is most appropriate in the differential analysis of white blood cells and entire blood cell counts. This is mainly because of the extent it preserves cells. Presently, the anticoagulant that the International Council for Standardization in Haematology recommends for full blood counts is the dipotassium salt of EDTA (England et al., 1993). This is the most commonly preferred anticoagulant across Europe and Japan although the UK and the US have been…

drug. the lawsuit against Pradaxa also alleges that the drug maker failed to provide instructions for care while using the drug, failed to undertake proper drug safety and dosing and the drug manufacturer failed to disclose the risks of internal bleeding and other injuries. The other plaintiffs are shocked that the drug maker released a drug without an antidote for public use. Pradaxa sales hit a staggering $1.2 million in 2012 and by May 2014 sales had hit $2billion according to IMIS Health.…

about the medication that they are taking. Xarelto is a newer medication used to prevent the risk for VTE, stroke, and heart attacks. (Drugwatch,2015) The medication is known to cause uncontrollable bleeding. Xarelto does not have an antidote to reverse the bleeding. Patients were placed on Xarelto and began to have complications, causing them to be hospitalized. Many patients filed lawsuits due to the lack of information and negligence by the Xarelto company. According to this popular source,…

teach Quranic lessons to the young girl, and attend religious conferences. However, after her stroke, she said she only wanted to stay home. She found herself afraid of falling because of her unsteady gait. She also did not like the way people were looking at her with pity. PC was not involved in any community activities. PC is currently seeing her doctor every two months to manage her diabetes, and to check for any blood clots. She developed a wound around her right ankle. The doctor put her…

Anticoagulants are medications that stop the blood from thickening as rapidly or as efficiently as normal. Anticoagulants medicines people referred to as blood thinners. However, the blood is made any thinner or the medicine make it more dilute. The blood thinners just prevents the blood from clotting. Anticoagulants are given to patient to treat and avoid blood from clotting in the blood vessels. Blood that clumps or clots, can block blood vessels and hinder the blood flow in the artery and…

Successful Aging Interview The person I interviewed was Stasia Zedilko, a 79 year old woman living in Las Vegas. I met Stasia by chance, when she came into my work one day, shaking and struggling to walk, with concern of her health and safety related to encounters of elder abuse. I work at the Center for Social Justice on campus, and she stumbled upon the building I work in when trying to find directions to a resource that could help her. Stasia lives alone here in Vegas, with no support system…

Anticoagulants are blood thinning medications that are used for the treatment and prevention of blood clots. They act mainly by slowing blood clot formation and thus preventing associated complications1.Their approved Food and Drug Administration (FDA) indications include prophylaxis and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE) and preventing complications associated with atrial fibrillation such as stroke2. For the past years, vitamin-k antagonist (warfarin) has been…

threatening allergic reaction when the physician orders a CT scan with IV contrast. (Bártlová et al., 2015) Another common danger is inaccurate medication lists. Consider anticoagulants, for example. These are important and potentially life-saving medications that can prevent strokes or heart attacks. But if a caregiver is unaware that a patient is taking anticoagulants, they may prescribe another, seemingly unrelated medication (antibiotics for treatment of a minor infection, for example) that…