Thalassemia

uptake is mediated via transferrin. Chelation therapy with desferoxamine before the age of puberty has helped patients to attain normal sexual maturation in some studies but not in others. In a study of 40 patients with transfusion-dependent thalassemia major, 90% of 19 patients who began treatment with desferoxamine before the age of 10 had normal sexual development compared with only 38% of those treated after the age of 10 (5). In contrast, another study reported no difference in the…

According to the article “Managing Sickle Cell Disease”, sickle cell disease is an inherited disorder affecting the red blood cells. The disease causes the red blood cells to become rigid and half-moon shaped, resulting in obstruction of capillary blood flow. Decreased oxygen to the tissues results in pain. The disease is inherited and has the greatest prevalence among Black Americans and Hispanics in the United States. Inheritance is autosomal recessive and results in production of sickle…

What is one thing that people would like to see a little less of in the world? Most people would agree that the world would be a far more enjoyable place if there was less pain and suffering. Specifically, if there was less disease. People do not wish disease upon themselves, loved ones, or anyone for that matter. Although, medicine has evolved tremendously over the past century, there are still many bodily conditions that are yet to be treated. Thankfully, new advancements in technology and…

What is Sickle Cell Disease? Sickle cell is an inherited blood disorder that affects red blood cells. People with sickle cell disease have red blood cells that contain mostly hemoglobin. Sometimes these red blood cells become sickle-shaped and have difficulty passing small blood vessels. Hemoglobin is the main substance of the red blood cells. It can help red blood cells carry oxygen from the air in our lungs to all parts of the body. Normal red blood cells are soft round and can squeeze through…

Sickle Cell Anemia is a birth defect that is “a genetic blood disorder caused by the presence of an abnormal form of hemoglobin” according to MedicineNet.com. Sickle cell is common to people that have ancestry with Africans. Sickle cell affects about 100,000 Americans, one out of every 365 African American babies, and one out of every 16,300 hispanic babies. Older children and adults with sickle cell disease may experience a few complications, or have a pattern of ongoing problems that make…

Haemoglobin is made up of globular protein and an iron- rich compound known as haem. It is found in red blood cells and is involved in the transport of oxygen around the body. Red blood cells do not have a nucleus, increasing the amount of space for haemoglobin. There are approximately 300 million haemoglobin molecules in each red blood cells. The structure of haemoglobin enables it to carry oxygen with high efficiency. It has a quaternary structure made up of four globin subunits, most commonly…

variations occur within each culture that may or may not predispose its’ members to specific illnesses. With reference to Italian-Americans, genetics may put them at a significantly higher risk for developing certain anemia disorders, such as favism and thalassemia. Favism is a type of hemolytic anemia that is commonly diagnosed among the culture. It is an X-linked genetic disorder that typically results in insufficient levels of the glucose-6-phosphate dehydrogenase enzyme. The irregular…

I would suggest to Audrey and Andrew to go about having the children using in vitro fertilization and pre-implementation diagnosis. In order to maximize the benefits and minimize the harm, by doing so, even though there is a possibility of having mosaicism, they know for sure that their child would not have Duchenne Muscular Dystrophy, which will affect their child greatly if they have the disease. With 24% pregnancy rate, they can have a child without the disease. Therefore, the benefits in…

The underlying diseases leading to the transplant include thalassemia and various forms of leukemia, categorized into five classes of acute lymphoblastic leukemia (ALL), acute myeloge nous leukemia (AML), chronic myelogenous leukemia (CML), plasma cell leukemia (PCL), or others. The pretransplant attributes consist…

Sickle Cell Disease : causes a blood disorder that leads to anemia , you then get a weakened immune system Thalassemia : is another blood disorder. It typically causes anemia and bone growth and liver problems; in severe cases some babies born with the condition may not survive. Fragile X Syndrome : a condition that can cause developmental problems, including learning…