Thalassemia

Thalassemia is known to be an inherited genetic blood disorder that results in mild to severe anemia due to the abnormal formation of hemoglobin. Thalassemia is inherited by either one or both parents. A mutation in either chromosome 11 (Deisserot et al, 1978) effect the synthesis of beta hemoglobin, whereas a mutation on chromosome 16 affect the synthesis of alpha hemoglobin(Deisserot et al, 1977). Hemoglobin is a tetramer made of two alpha chains and two beta chains (Cao et al, 2010). The location of the mutation in the hemoglobin chains is what characterizes the severity and type of thalassemia. Geographically thalassemia is commonly found in places like south-east asia and china (Charoenphandhu et al, 2011). There are two types of thalassemia,…

the disease known as thalassemia, and while there may only be 200,000 cases of thalassemia per year in the United States, the disease is much more prevalent in the Eastern side of the world. There are several types of thalassemia, and the disease is also known as Cooley’s anemia or Mediterranean anemia. The disease is autosomal recessive, meaning that if both parents are unknowing carriers of thalassemia, there is a one in four chance of their children having the disease. Patients who have…

Abstract Sickle cell disease is an illness in the blood that normally affects people of African American descent, as well as people of Mediterranean and Middle Eastern origin. There are numerous types of sickle cell disease. The three most common are HbSS, HbSC and HbS Beta Thalassemia. There are also rare types such as: HbSD, HbSE, and HbSO. Sickle cell disease is an inherited disease. It is caused by receiving two abnormal genes from both parents, who either have the disease themselves or are…

red blood cells. Example of the disease is alpha-thalassemia. This happens due to lack of one or two series of alpha-Zhlobin or beta (where the shortfall in one or two Zhlobin beta), for example, inheritance thalassemia is inherited through a recessive trait autosomal recessive physical. There are differences between the alpha thalassemia and beta thalassemia. Alpha symptoms are usually immediately after birth no need time for the appearance of the period and the second is that the alpha chain…

parasite that infects red blood cells (“Sickle Cell Disease: Learn.Genetics”). This also reduces the amount of parasites that attack and infect the susceptible host, giving them more protection than others (“Sickle Cell Disease: Learn.Genetics”). That is the only case in which any type of sickle cell disease or trait is beneficial to the sufferers. The types of sickle cell disease differ greatly because of the protein Hemoglobin. The first type of sickle cell disease is Sickle Beta Thalassemia,…

classifications of anemia are, microcytic, macrocytic, normocytic, and hemolytic anemia. (Buttarro, Trybulski, Polgar Bailey, Sanberg-Cook 2013). The purpose of this discussion is to review microcytic anemia, which could be the cause of the decreased hemoglobin level in case study two. Differential diagnosis: Iron deficiency anemia (IDA): IDA is a common nutritional deficiency anemia found in women of reproductive age, and older adults due to gastrointestinal blood loss or menorrhagia…

It happens when you acquire copies of the hemoglobin S quality from both parents. This structure of hemoglobin known, as Hb SS. Hemoglobin SC disease is the second most usual kind of sickle cell disease. It happens when you recieve the Hb C quality from one parents and the Hb S gene from the other. People with Hb SC have comparable side effects to people with Hb SS. Be that as it may, the anemia is less serious. Hemoglobin SB+ (Beta) thalassemia influences beta globin gene making. The red blood…

Anemia of chronic disease is suspected in patients with microcytic or marginal normocytic anemia with chronic infection, inflammation, or cancer (Alan ;2013). Anemia is often mild enough that it does not need treatment. It will likely get better when the disease that is causing it is treated.The condition is rarely severe enough to need a blood transfusion.Iron supplements may sometimes be used, but only for patients whose iron levels are low. (little ;2012). 3_Thalassemia Thalassemia, also…

Hello Dr. Julian, Thank you for reading my discussion post case study # 2, and perspective question. Lead poisonousness is a global problem, while arrays of research information indicated a deterioration in the predominance of upsurge blood lead echelons in children from the developed world, lead lingers as a widespread avoidable ecological health hazard. The CBC analysis has an enormous effect on lead poisoning, the CBC laboratory appraisal answers arrays of question-related to quantity of…

One example is the prevention of β-thalassemia. This is an autosomal recessive disease caused by a mutation on the HBB gene that is responsible for the production of β-globin, which is a protein that forms part of haemoglobin. Some mutations to this gene decrease the production of β-globin and others inhibit it completely. With less β-globin, less haemoglobin is made and so less oxygen is delivered around the body. The CRISPR-Cas9 technique has been tested and could be used in the future to…