I would suggest to Audrey and Andrew to go about having the children using in vitro fertilization and pre-implementation diagnosis. In order to maximize the benefits and minimize the harm, by doing so, even though there is a possibility of having mosaicism, they know for sure that their child would not have Duchenne Muscular Dystrophy, which will affect their child greatly if they have the disease. With 24% pregnancy rate, they can have a child without the disease. Therefore, the benefits in this case would outweigh the risk of having mosaicism that might leads to different types of mutations including the silence mutation. The CRISPR/Cas9 is very appealing to the scientist for editing genome at disposable. However, the system has limited success
