Busulfan plus cyclophosphamide and cyclosporine used in transplantation may be responsible for gonadal damage, which was observed primarily in prepubertal girls whereas the same study found no obvious gonadal damage in boys (34)]. It is important to counsel patients on the pros and cons of bone marrow transplantation regarding fertility issues, especially concerning the ovaries, since ovarian failure is a common occurrence (19)]. In contrast, patients undergoing conventional treatment usually have hypogonadotropic hypogonadism, but pregnancy is still possible using hormonal
Busulfan plus cyclophosphamide and cyclosporine used in transplantation may be responsible for gonadal damage, which was observed primarily in prepubertal girls whereas the same study found no obvious gonadal damage in boys (34)]. It is important to counsel patients on the pros and cons of bone marrow transplantation regarding fertility issues, especially concerning the ovaries, since ovarian failure is a common occurrence (19)]. In contrast, patients undergoing conventional treatment usually have hypogonadotropic hypogonadism, but pregnancy is still possible using hormonal