Sickle

there were to be any mutations within the stages of replication, the life created could have abnormalities which may decrease quality of life experienced. Sickle cell anaemia is a hereditary form of anaemia in which a point mutation causes the formation of haemoglobin which distorts the erythrocytes into a sickle-shape (Appendix 1). The sickle cells are not able to flow through blood vessels as easy as the disc-shaped erythrocytes (Appendix 2) resulting in blocked blood vessels which could,…

Plasmodium parasites that can be deadly (Lee, 2018). Sickle cell anemia is a form of anemia where an abnormal hemoglobin changes the shape of the red blood cells. Whether or not you have sickle-cell depends on your genotype. Individuals who have the genotype AA (HbA) have "normal" blood and no mutations which can lead them to contracting malaria more easily because they don't have protection. People with the AS genotype, (HbA & HbS) have the sickle cell trait because they have one normal…

Sickle Cell Anemia India is one of the biggest countries with a population of 1.3 billion, but with a high population comes a high percentage in disease specifically sickle cell anemia. Sickle cell anemia’s history goes as far back as 1846, since numerous discoveries have been made in understanding how sickle cell manifests. Therefore Dr. Herrick in 1910 was the first to distinguish the “pelicular elongated and sickle shaped” platelets (Vasaikar, 2015). While in 1949 sickle cell was identified…

Sickle Cell Anemia: Sickle Cell Anemia (SCA) is the most common and severe form of sickle cell disease, and is caused by a genetic mutation that results in an abnormal formation of hemoglobin called hemoglobin S. SCA is an autosomal recessive disease, and the individual can inherit the hemoglobin S gene from both parents. Sometimes, an individual can inherit this gene from one parent and have a normal hemoglobin gene from other parents, and are called sickle cell trait. Individuals with sickle…

According to World Health Organization, Sickle Cell Disease is an inherited blood disorder affecting red blood cells and is the most common genetic diseases in the U.S. Although Sickle Cell Disease largely affects African Americans, it affects other ethnicities too, including those of Mediterranean, Caribbean, South American, Southern European, Indian and those of Middle Eastern descent. The proponents believed that this disease can have a devastating effect on the lives of many people. The bill…

important allele is the S beta chain responsible for sickle cell anemia, it differs in one amino acid from a normal beta-chain. At the beta gene locus, two possible alleles have two base sequences A = normal beta-chain and S = sickle-cell beta chain. Sickle cell anemia is due to abnormality of hemoglobin, a (protein carrying oxygen to the tissues). “Anemia is a decrease in RBCs; or hemoglobin; or ability to carry oxygen. Hemoglobin S (allele HbS) causes Sickle Cell Anemia, without hemoglobin S,…

chromosomes which contain between 20,000 to 25,000 genes, some of which determine their inherited physical traits such as eye colour, skin colour, and body shape. Offspring can also inherit some non-physical traits from their parents including disease. Sickle Cell Anaemia is one example of inherited disease which can be passed from parent to offspring. Every living organism inherits genetic information from its parents. Genetic material is incorporated within the DNA of every living thing which…

taken by the RN to reduce the stigma and improve management of acute and chronic pain associated with Sickle Cell Disease, (SCD). One intervention that comes to my mind after reading the articles would be recognizing the cues to an acute pain episode and responding appropriately and in a timely manner (Jenerette & Ataga, 2014). By doing so, it could help manage the chronic pain associated with sickle cell disease. Patients with SCD are often stigmatized as addicted to opioids, disbelieved or…

children in the future (GuideStar, n.d.). For example, Dr. Jane Hankins, a hematologist from St. Jude Children’s Research Hospital, along with her team, are heading up a project called the “Sickle Cell Clinical Research and Intervention Program” (SCCRIP) (Walker, 2017). Their goal is to find a cure for the sickle cell disease (Walker, 2017). For this project, children have agreed to return back to St. Jude for periodic checkups throughout their lives. Not only will this help the children…

Sickle cell anemia is considered a codominant gene mutation which means that both parents have two genes that cause the abnormal hemoglobin (Crowley & Crowley, 2014). If the person has the sickle cell trait it means that they only carry one defective gene, and would live a normal life. In order for the sickle cell to be anemia the individual would have to have one defective gene from the mother and the other from the father. Every newborn in the United States undergoes a mandatory test that…