Histone

transcriptional machinery of RNA Polymerase I in the oocyte Experimental Approach: Aim1: To address the roles of the Hira complex in rRNA transcription and embryonic development The Hira histone chaperone complex is an evolutionarily conserved complex, which is composed of Hira, Ubn1 and Cabin1, and cooperates with the histone chaperone Asf1a to mediate H3.3-specific binding and chromatin deposition12,13. I previously demonstrated the critical roles of maternal Hira /H3.3 on paternal…

Formaldehyde, the most simple’s aldehyde, is a widely used agent, abundant in the environment and naturally made in organisms, is a well know carcinogenic to many organisms. The US National Toxicology Program composed of US agencies like NIH, the FDA, and the CDC have grouped formaldehyde as an agent “known to be carcinogenic” (CDC, 2014). The mechanisms by which formaldehyde produces its carcinogenic affects and the mechanism by which the cell repairs these aberrations inflicted on DNA is not…

loop of DNA (nucleosome), no cellulose, cytoplasm, cell membrane, cell wall (made of carbs), sometimes have cilia or flagella (movement). Eukaryotic Cells are larger cells, complex, with nucleus, membrane bound organelles, DNA tightly wrapped around histone proteins in chromosomes, cellulose in plant cell walls. 3. Chloroplasts are present in plant cells but not animals. They do photosynthesis and make energy. Also, cell walls, which provide structure to plant cells, are not present in animal…

The variation could be inherited and be a part of the studied individual and therefore even be in its germline. This is called transgenerational epigenetic inheritance and proofs that epigenetic markers can be inherited, even though it is not exactly understood how (Rakyan et al. 2011b). Also, Stochastics are an important factor in epigenetic variation. If the variation occurs early, like in the utero, it can affect the whole body of the individual, but If it occurs after birth or later in life…

Decreased R-2-HG levels reduce the anomalous histone hypermethylation, reduction in blasts count and restores differentiation function of myeloid cells, results increased the count of mature myeloid cells. Enasidenib's phase I/II results have shown a response rate of 37% in 159 patients having R/R-AML…

Codominance is between true breeding (both parents are homozygous and one is homozygous dominant, while the other is homozygous recessive), and the offspring is heterozygous. The phenotype of both parents are present in the offspring. An example of codominance is if a white flower (rr) and a red flower (RR) breed to produce an offspring (Rr), whose phenotype is red and white stripes, therefore showing that both parents’ phenotype is present. Incomplete dominance is also between true breeding,…

nutritional exposure during pregnancy could induce epigenetic changes in metabolic tissues of the offspring. There is increasing evidence that obesity has developmental origins such as, an exposure to a suboptimal nutrient supply before birth or in early infancy is associated with an increased risk of obesity and metabolic disease in later life(McMillen, Adam and Mühlhäusler, 2005; Waterland and Michels, 2007; McMillen et al., 2008). Animals studies have been performed to provide evidence that…

center of the cell, the nucleus, for this reason [2]. However, the amount of DNA that each cell contains is too much to fit into the nucleus without being compacted. To compact the double helix of DNA, the double helix wraps around proteins called histones to form chromatin…

The title of the video, “Ghost in your Genes”, is very appropriately titled because it discussed the various appearances of phenotypic differences among organisms with identical genomes. In the mid to late 1900s, scientists were convinced that DNA sequences were solely responsible for every trait evident in organisms. After the human genome experiment, which involved compiling and analyzing genomes of thousands of different people, it was determined that humans have around 25,000 genes, far…

I am writing to express my interest for the PhD position in your working group on the topic of haematopoietic cancer research.I had always been interested in immunological responses and I would be very excited to apply it together with my skills and knowledge to make a step against cancer. I dream to be part not only of basic science but also to make an investigation that can be directly applied for the sake of humanity. Reading the papers from your group, brought me to conclusion that I not…