Beta amyloid

progressive brain disorder that slowly destroys memory and thinking skills, and eventually the ability to carry out the simplest tasks,” (Fact). Alzheimer’s disease is the most common form of dementia (Association). It causes disturbances in metabolic processes that are vital to keeping neurons healthy. These disturbances cause nerve cells to stop working, lose connection with other nerve cells, and eventually die. This causes memory loss, behavioral issues and problems with critical thinking (Fact). Causes Amyloid plaques are essential when it comes to Alzheimer 's disease. Plaques are abnormal clusters of protein fibers between the nerve cells, as seen in Figure 1. They can be formed when pieces of a protein, also known as, beta-amyloid, begin to bundle together. The beta-amyloid are smaller pieces to a large protein that is found in the fatty membrane surrounding the nerve cells. Beta-amyloid stick together and eventually form plaques. Small clumps of beta-amyloid are more damaging than the larger ones. This is because the small clumps can possibly block the cell-to-cell synapses. Although, scientists have not been able to link plaques to the cause of the disease. Some believe that it is a byproduct of Alzheimer’s disease.…

In order to understand the hypothesis, first we must understand what is amyloid-beta, and how it is synthesized. Amyloid-beta is a peptide cleaved from the amyloid-beta precursor protein, which is a larger integral membrane protein found concentrated in neuronal synapsis (Masters et al., 1985;Glenner & Wong, 1984). An existing mutation in APP would lead to an increased cleavage and to a different availability of its sub products, hence increasing the amount of amyloid-beta being synthesized. A…

Alzheimer’s disease (AD) was first discovered in 1907 by Alois Alzheimer, a German psychiatrist and neuropathologist. He noticed that the brain tissue of a recently deceased woman was exhibiting strange abnormalities. Upon further examination he discovered abnormal clumps and tangled fibers; which are now known as amyloid plaques and tau tangles. Alzheimer’s disease is an irreversible and progressive brain disorder characterized by memory loss and loss of cognitive abilities. While Alzheimer’s…

INTRODUCTION Alzheimer’s disease is a progressive neurodegenerative disorder characterized by memory loss and dementia. The neurodegeneration is due to a formation of amyloid platelets in the brain that interrupt the normal function of it. It worsen with the pass of years and is mostly suffered by older people (Reece et al. 2014). The platelets composed by Amyloid; a harmful insoluble protein fibril which is produced by Amyloid precursor protein (APP). APP is processed in the membrane of neurons…

Herrup attempts to disprove the hypothesis and looks forward to other possible hypothesis. After looking pointed towards animal studies, it was seen that animals can have large amyloidal burdens in their brains but still do not have any signs of dementia (Herrup, 2015). This shows that although the hypothesis could show that there are cases where people have the large burden and have Alzheimer’s disease, it is also possible that a person with the disease does not need to have the amyloid…

and sulfur. There are many different kinds of proteins, each with a different function. Collectively, they are essential for the proper functioning of an organism” (Comer, 2014). Comer also explains that, “The plaques and tangles that are so plentiful in the brains of Alzheimer’s patients seem to occur when two important proteins start acting in a frenzied manner. Abnormal activity by the beta-amyloid protein is key to the repeated formation of plaques” (2014). Researchers have found that…

I started studing about nutrion and the medical field over five years ago, I was very interested in this field due to my disabilities. I read about eicosanoids and the effects of long, medium and short chain fatty acids and what could enhance my quality of life. Later pursing information about the human microbiota and how our gut microbes effect our health. Knowing how Amyloid Beta Protein can effect my brain I aslo studed about what I could do to eliminate the accumulating Amyloid plaque. I…

Five million Americans have Alzheimer’s Disease and it causes up to 500,000 deaths each year (Marsa, 2015, p. 6). Alzheimer 's is a brain disorder, which currently has no cure, it not only affects the patient but the loved ones surrounding them.This disease causes problems with judgement, memory and overall thinking. In the human brain, plaques are clusters of protein fragments called beta-amyloid peptides (Marsa, 2015, p. 7). They collect outside the nerve cells and disrupt the signaling…

Amyloidosis is an incurable fatal disease where abnormal proteins called amyloid fibrils are misfolded and then deposited in the tissues and organs of the body. It is a serious condition that can affect one organ or tissue or multiple organs at the same time. This study was performed to analyze and describe the latest clinical trials, research, diagnosis procedures, treatment plans, and drugs available for the treatment of amyloidosis AL (primary), AA (secondary), ATTR (hereditary and senile),…

mouth twice daily, to control his blood sugar levels for his type 2 diabetes. Metformin (Glucophage) is used to help to lower blood sugar when it is too high and help restore the way you use food to make energy (“Metformin (Oral Route),” 2015). Methylprednisolone (Solu-Medrol). Mr. Borg was prescribed methylprednisolone (Solu-Medrol) 500 mg IV daily, to help reduce inflammation in the lungs. This medication is a corticosteroid that works on the immune system to help relieve swelling…