Thrombosis

fibrinolytic and antithrombotic therapy in ACS established in practice the role of thrombosis in their pathogenesis. A number of micro anatomic mechanisms underlie acute coronary thrombosis. The rupture of plaque’s protective fibrous cap can, most commonly cause lethal coronary thrombosis, according to autopsy studies. [14] This physical disruption of the atherosclerotic plaque results in almost all acute coronary thrombosis. Once platelets are exposed to the ruptured…

continuity of care and decrease complications. Central line infection and thrombosis cause thousands of deaths each year and increases medical costs (CDC). Proper care of the central line utilizing antibacterial dressings, passive disinfection caps and pulsatile flushing can decrease infection. Properly obtaining blood specimens can result in faster identification of bacteria and proper intravenous (I.V.) antibiotic administration. Thrombosis can be decreased with proper flushing and monitoring.…

Most people could probably guess that heart disease and cancer are the leading causes of death, but many may not know that strokes are the fourth leading. Strokes are also one of the leading causes in long-term adult disability. A stroke occurs when there is a clot in a blood vessel or an artery located in the brain, interrupting or severely reducing blood flow to the brain, preventing it from getting the oxygen it needs. There are two different types of strokes, and there are multiple types…

The patient is a 32-year-old female presenting with multiple modifiable risk factors in combination with a potential venous thromboembolism (VTE) derived pulmonary embolism (PE) in progress. The following study identifies the risk factors for VTE, assessing their contribution to the presenting complaints experienced by the patient. Modifiable risk factors identified in this patient include the use of mixed (containing both progestin and Ethinyl estradiol) oral contraceptive pill (OCP), smoking,…

Argatroban Argatroban is a synthetic direct thrombin inhibitor. It binds reversibly to thrombin so it requires to be given as a continuous intravenous infusion. It is metabolized mainly by the liver so it needs dose reduction in liver impairment. Its half-life is moderately extended in renal impairment. The effect of renal impairment on argatroban dosage adjustment is unclear. Some studies which were done on dialysis patients used the same dose in normal renal patients with no additional adverse…

1. Coronary perfusion is a crucial factor in meeting cellular oxygen demands, which of the following factor can cause the decline in coronary perfusion? a) Heart Rate b) Contractility c) High blood pressure d) Platelet aggregation and thrombosis Answer: D Answer Rationale: A. (Incorrect) Heart rate and coronary perfusion is not correlated. An increase or decrease in heart rate along does not necessarily impact the coronary perfusion. In most cases, it is the vasodilation and vasoconstriction…

Review Questions # 5 2. Distinguish between autosomal dominant and autosomal recessive disorders and provide a couple examples of each. When dealing with genetic disorders its important to understand how they are inherited. There are two ways a child can inherited a genetic disorder from their parents. Autosomal dominant disorder is where one parent has a genetic disorder in which it has already manifested such as familial hypercholesterolaemia, marfan’s syndrome, and…

Being immobile for long periods of times cause enzyme changes that elevate your blood sugar levels, and not even an hour at the gym can undo these effects of sitting all day. Deep Vein Thrombosis This is one of the deadly effects of sitting all day. You’re probably most familiar with Deep Vein Thrombosis, potentially fatal blood clots that can form in your legs, from warnings you encounter on airplanes while traveling long distances. However, any time that you are sitting without moving for…

There are five main common venous disorders, and several of them have the same symptoms, even though some are more serious than others are. Some disorders result in cosmetic issues rather than serious medical issues, as they are unsightly, but they also cause discomfort. During a consultation with our specialist, you can express your concerns and have an examination of your veins. Here are the most common venous disorders and their symptoms and treatments. • Chronic venous insufficiency (CVI)…

Introduction: Venous thromboembolism (VTE) [i.e., pulmonary embolism (PE) and deep vein thrombosis (DVT)] is a common complication during and after a hospital admission. Further, VTE is a leading cause of major complications and death after major orthopedic surgery. To avoid the development of VTE after orthopedic surgery, it is essential to reduce the onset of deep vein thrombosis (DVT) and to diagnose DVT early. It leads to early diagnosis to find a risk factor of DVT from medical history of…