Coagulation system

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  • A Brief Experimental Design Of Experimental Approaches

    Budget Justification Personnel Vijaya M. Lella (also known as L. Vijaya Mohan Rao), Ph.D. Principal Investigator, 3.6 calendar months effort and salary. The P.I. will devote 30% of his effort on the proposed grant. He will assume overall responsibility for the proposed project, which includes supervision of all personnel involved in the project, planning, the design of experimental approaches, the close review of the data, data analysis & interpretation, preparation of manuscripts, and decisions as to priorities of activities and effort. The P.I. will also help the post-doctoral fellows and the research associate in purification of FVIIa variants and their characterization. Usha Pendurthi, Ph.D. Co-investigator, 3.0 calendar months effort and salary. Dr. Pendurthi will help in the overall experimental design of the proposed study, data analysis and manuscript preparation. In addition, Dr. Pendurthi will help the post-doctoral fellow and the research associate in generating novel FVIIa derivatives, including primer design, cloning, transfection and expression of the proteins. Shiva Keshava, Post-doctoral fellow, Ph.D., 12 calendar months effort and salary. Dr. Keshava has been working in the laboratory for the last 4 years. He is well trained in animal procedures, including tail vein injection, saphenous vein bleeding, and needle puncture knee injury. He is also expert in the immunohistochemistry. He is responsible for performing majority of animal experiments described…

    Words: 761 - Pages: 4
  • Vete Case Study Essay

    Question 1 The risk factors that predisposes Mrs. X to develop a venous thromboembolism (VTE) are: advanced age, malignancy (cholangiocarcinoma), trauma (multiple falls), and recent major livery surgery (Schwartz & Rote, 2014, p. 1048-1050). Patients who are in their advanced ages are at risk in developing a VTE due to slower blood flow in their veins (Schwartz & Rote, 2014, p. 1048). Additionally, malignancy, trauma and post-operative state are examples of secondary or acquired…

    Words: 1092 - Pages: 5
  • Type B Hemophilia Case Study

    Introduction Originating from the Greek words ‘haima’, meaning blood, and ‘philia’, meaning friend, hemophilia is a medical condition in which the individual lacks a certain clotting factor which prevents bleeding as a result of injury. In order of rarity from most to least, it features type A, B and C hemophilia and various severity levels. Type A hemophilia consists of 90% of cases, in which the individual lacks clotting factor VIII and 70% of patients have a severe level of hemophilia.…

    Words: 793 - Pages: 4
  • Essay On Pros And Cons Of Horror Films

    with a 17 % increase in the risk of venous thrombosis” (Westbrook). Seventeen percent isn’t a small number especially when followed by the following word: increase. This study shows that subjects have at least a seventeen percent increased chance of experiencing a blood clot in the veins. This doesn’t even take into account for individuals who are already vulnerable to clotting and heart malfunctions who may have an even greater increased risk. So how could someone really think horror movies…

    Words: 1945 - Pages: 8
  • Hard Dreamer Case Study

    like in the cases previously presented the minor cases described bleeding from minor cuts, scrapes, brushing your teeth is all magnified 100 times more versus a regular individual. Hemophilia is a “rare bleeding disorder which means it’s an inherited disease, but also you can get it from another source described later. Hemophilia is defined by a “deficiency or absence of one of the 20 blood proteins that helps our blood clot” (Foundation, 2011). Individuals with hemophilia are unable to form…

    Words: 1422 - Pages: 6
  • Bleeding Disorder Research Paper

    When Blood Takes Away from Your Life - Rodney Lemay What is a Bleeding Disorder: Quality of life is a very important aspect to consider and if that can be improved upon, it is wise to do so. Bleeding disorders often fall unnoticed and can have harmful effects on the body. Many people even put up with the symptoms of a bleeding disorder without even knowing that they are doing so. A bleeding disorder can go unchecked as they are commonly relatable to a woman 's period for example. The usual side…

    Words: 1003 - Pages: 4
  • Hemophilia Research Paper

    Hemophilia is a genetic blood disease, which is symbolized by the importance of blood to clot, or compact even from inconsequential damage. Blood clotting and sudden gene mutation factor in the development of this disease. This disease is generated by an inadequacy of blood multifaceted called factors Therefore, with the nonappearance of factors, the blood clotting process is continued. There are two different types of Hemophilia, Hemophilia A and Hemophilia B. for example. Hemophilia A, the…

    Words: 1309 - Pages: 6
  • Erickson's Development Theory

    surgery the body attempts to heal damaged tissue to stop the bleeding and close the wound. Blood cells and clotting factors work together to create a protective scab over the surgical incision. This occurrence is known as the clotting process. According to Greengard, the surgical procedure may stimulate clots to form in error in blood vessels, which may block the normal flow of the blood (Greengard, 2015). Vessel damage caused by the surgery also contributes to DVT formation. Obesity contributes…

    Words: 1623 - Pages: 7
  • Venous Thrombosis Pathophysiology

    malignancy, pregnancy, and the use of contraceptive pills. Certain genetic abnormalities such as V leiden mutation, deficiency of protein S, deficiency of protein C, homocysteine deficiency, deficiency of antithrombin, and prothrombin mutations have been linked to development of DVT. The primary etiology of DVT is accumulation of platelets and clotting factors leading to the formation of thrombus in the veins primarily in the lower extremities. Thrombus in the veins causes inflammation that…

    Words: 1028 - Pages: 5
  • Blood Clot Analysis

    thrombus can form when there is damage in the lining of a blood vessel, either in an artery or a vein (MedicineNet, 2015). In addition, clots occur when the blood stops circulating, becomes idle, or in diseases that result in abnormal blood clotting. There are times when a thrombus will form when it is not needed and can potentially lead to significant consequences. Damages can be greatly obvious, but at times other times, they are difficult to detect. Poor clotting with a minor injury to a…

    Words: 1359 - Pages: 5
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