Coagulation system

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    Introduction Originating from the Greek words ‘haima’, meaning blood, and ‘philia’, meaning friend, hemophilia is a medical condition in which the individual lacks a certain clotting factor which prevents bleeding as a result of injury. In order of rarity from most to least, it features type A, B and C hemophilia and various severity levels. Type A hemophilia consists of 90% of cases, in which the individual lacks clotting factor VIII and 70% of patients have a severe level of hemophilia. Type B hemophilia is far less common, in which the person lacks clotting factor IX. (Crosta, P. 2013) Type C hemophilia is when the patient lacks clotting factor XI, can appear in both males and females, but is ten times less common than type A. Patients with a factor level of 0 to 1% are considered severe, in which they may have extensive spontaneous bleeding, including internal bleeding that the person may not even be aware of. Joints may bleed and blood may get into the muscles, which can cause lifelong damage. Severe hemophilia is unfortunately the most common variety. Ten percent of hemophiliacs are considered moderate (1 to 5%), in which they may suffer from spontaneous bleeding and will likely have prolonged bleeding. Another ten percent of hemophiliacs are considered mild (5-50%), in which the individual is likely only to suffer from prolonged bleeding that may not even be noticed until adulthood. (Types of hemophilia and other bleeding disorders, 2013.) Hemophilia is…

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    Hemophilia Research Paper

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    Hemophilia A, B, and C. Hemophilia A and B are the most common types. In the past hemophilia affected life expectancy but currently with improved treatment, individuals with hemophilia will have a normal life span. . There are several harmful effects on the body because of hemophilia. Bleeding can occur in muscles and can cause limbs to swell which may lead to numbness or pain. Internal bleeding can also put pressure on joints which causes severe pain. If left untreated, the frequent bleeding…

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    Vete Case Study Essay

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    Question 1 The risk factors that predisposes Mrs. X to develop a venous thromboembolism (VTE) are: advanced age, malignancy (cholangiocarcinoma), trauma (multiple falls), and recent major livery surgery (Schwartz & Rote, 2014, p. 1048-1050). Patients who are in their advanced ages are at risk in developing a VTE due to slower blood flow in their veins (Schwartz & Rote, 2014, p. 1048). Additionally, malignancy, trauma and post-operative state are examples of secondary or acquired…

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    Hemophilia Research Paper

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    and B. Hemophilia A is caused by a mutation in the F8 gene and hemophilia B is caused by a mutation in the F9 gene [7]. Mutations in both genes cause abnormal production of two proteins, coagulation factor VIII (Hemophilia A) or factor IX (Hemophilia B). Both coagulation factors, along with other factors, are responsible for forming blood clots after an injury. Coagulation factor VIII and IX are produced in inactive forms in the liver [8]. Factor VIII is activated when it binds to another blood…

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    The thrombocytes that have undergone the process of degranulation also release Adenosine diphosphate, a substance that promotes more thrombocytes to adhere to each other. The aggregation of these thrombocytes forms a temporary ‘plug’ and, on average, takes around 6 minutes to develop after the damage occurs (Waugh and Grant, 2014). Sometimes, this stage is enough to prevent further bleeding, however, in Rosemary’s case; her bleeding didn’t stop for a while. Therefore we know coagulation had to…

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    “Disseminated intravascular coagulation (DIC) is a life-threatening acquired pathologic process in which the clotting system is abnormally activated, resulting in widespread clot formation in the small vessels throughout the body. The pathophysiology is excess thrombin is generated, followed by deposition of fibrin strands in the body tissues.” (Ball, 2012) “The circulating fibrin fragments later begin to interfere with platelet aggregation and other aspects of the clotting mechanism, resulting…

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    Lesson Journal #3 Hemophilia involves different heredity inadequacies of coagulation factors resulting in prolonged bleeding times. The most classic form of Hemophilia is Hemophilia A. It seems that nearly all cases of Hemophilia A are reported in males and are characterized by bleeding in joints, gums, or mouth. Hemophilia B is the deficiency in the ability of the blood to coagulate. When parents who discover that their child has been diagnosed with a bleeding disorder, they may go through…

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    Description- Hemophilia is a hereditary disease where the body lacks certain blood clotting factors because of a defective gene. (worldbookonline.com) A hemophiliac’s blood lacks the active form of one of these factors.(worldbookonline.com) People with this disease experience excessive, or even fatal bleeding. (galegroup.com) Number of people affected – It is estimated that 10,000 people are born with this disease. It is a lifelong and chronic illness. (google.com) Life Expectancy- as of 2015,…

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    makes it a higher risk for early deficiency bleeding also making it more severe. Late vitamin K deficiency bleeding in 2-12 weeks after birth occurs in 1 in 14,000 infants. 30%-60% of these infants have bleeding within the brain and tend to occur in breastfed only babies who have not received the vitamin K shot. All pregnant women should be required to give their newborn the vitamin k shot if they plan to breast feed. What is Vitamin K? Vitamin K is a substance that our body needs to clot…

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    Blood Clot Analysis

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    thrombus can form when there is damage in the lining of a blood vessel, either in an artery or a vein (MedicineNet, 2015). In addition, clots occur when the blood stops circulating, becomes idle, or in diseases that result in abnormal blood clotting. There are times when a thrombus will form when it is not needed and can potentially lead to significant consequences. Damages can be greatly obvious, but at times other times, they are difficult to detect. Poor clotting with a minor injury to a…

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