Coagulation system

Von Willebrand Disease Von Willebrand disease is the most common bleeding disorder. It occurs when the body makes too little of the von Willebrand factor (VWF), a protein that helps blood clot, or when the VWF is misshapen and does not work the way it should. VWF is a carrier for another protein, called factor 8, that helps blood clot. When VWF levels are low or when VWF is not working properly, factor 8 levels are low as well and the body is less able to form stable blood clots. There are…

Hemophilia is a genetic disease that affects the blood. There are two types of this disease, they are classified as Hemophilia A and Hemophilia B. This genetic disease is most commonly found in males, although, the gene is passed down from the mother, the “carrier.” However, it has been discovered that hemophilia can occur in females, though it is rare. Hemophilia A is the classic type of this disorder where the affected individuals have a profound deficiency in Factor VIII, a part of your…

hemophilia was the most common coagulation factor deficiency and also had the highest associated treatment cost for a disorder. Life expectancy for people with Hemophilia is the same for regular people, because there is effective treatment.…

Early vitamin K deficiency bleeding occurs in 1 and 60 newborns born in the first 0-24 hours after birth. Mothers who used certain medications during their pregnancy makes it a higher risk for early deficiency bleeding also making it more severe. Late vitamin K deficiency bleeding in 2-12 weeks after birth occurs in 1 in 14,000 infants. 30%-60% of these infants have bleeding within the brain and tend to occur in breastfed only babies who have not received the vitamin K shot. All pregnant…

The F8 gene codes for the clotting factor VIII, which is a glycoprotein located in the blood that aids in the coagulation of blood in a blood clot. The gene is around 180,000 nucleotides long, including 26 exons.1 Those exons code for 2,332 amino acids.2 Hemophilia A is inherited through an X-linked recessive inheritance pattern because the F8 gene is located on the…

Budget Justification Personnel Vijaya M. Lella (also known as L. Vijaya Mohan Rao), Ph.D. Principal Investigator, 3.6 calendar months effort and salary. The P.I. will devote 30% of his effort on the proposed grant. He will assume overall responsibility for the proposed project, which includes supervision of all personnel involved in the project, planning, the design of experimental approaches, the close review of the data, data analysis & interpretation, preparation of manuscripts, and decisions…

Hemophilia is a medical condition in which the ability of the blood to clot is severely reduced causing the sufferer to bleed severely from even a slight injury. There are four types of Hemophilia which are Hemophilia A-Also called classic hemophilia, it is four times more common than Hemophilia B, and it occurs when factor VIII levels are deficient, Hemophilia B-Also called christmas disease, it occurs when factor Xi levels are deficient, Hemophilia C-It occurs when facts of XI levels are…

comes in contact with agents which activates the contact factors. PTT assesses intrinsic and common pathway of coagulation. Prothrombin time ( PT) measures the time needed for plasma to form a clot in the presence of tissue factor. PT evaluates extrinsic and common pathway of coagulation (Zehnder, 2017). In Hemophilia, the deficient factors are related to the intrinsic cascade of coagulation, therefore PTT is prolonged and abnormal. b. In which gender is this disorder common and why? • This…

Hard dreamer age 25 male a case of frequent disruption to studies & parents under emotional & financial stress. As a kid “he cuts his small toe when he was one years old resulting in an unusual bleed,” (Ramchander, 2009). Then he starts “bleeding frequently from different sites like his gums, nose & ears,” (Ramchander, 2009). Three years later he bleeds from his forehead & hip after a fall, he experiences a major bleed in the urinary tract, & lastly his right knee is swollen making his movements…

A wise American poet, Roger Zelazny, once said “The power to hurt has evolved in a direct relationship to technological advancement.” It is 2016: advancements are endless, especially when it comes to horror films. Think of the famous 1897 horror film Dracula; the blood that looked like blobs of ketchup, the large amounts of makeup on the actors, it all seems so fake now. With advancements in technology producers are able to create horror films with undeniable visual effects. Better visual…