Venous Thrombosis Pathophysiology

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This paper is scribed to present the compare and contrast between chronic venous insufficiency and deep venous thromboses. It will also present pathophysiology and treatment of the two mentioned diseases. The symptoms to the diseases may be identical although the anatomy is truly different.There is no exact amount of the people that are affected by chronic venous insufficiency and deep vein thrombosis although the estimated range is from 300,000 to over 600,000 each year in the United States. Approximately 60,000 to 100,000 Americans die of deep vein thrombosis (DVT) annually, ten to thirty percent of people will die within one month of diagnosis (CDC. 2013 p.1). Pathophysiology of Chronic Venous Insufficiency and Deep Venous Thrombosis …show more content…
Certain genetic abnormalities such as V leiden mutation, deficiency of protein S, deficiency of protein C, homocysteine deficiency, deficiency of antithrombin, and prothrombin mutations have been linked to development of DVT. The primary etiology of DVT is accumulation of platelets and clotting factors leading to the formation of thrombus in the veins primarily in the lower extremities. Thrombus in the veins causes inflammation that elicit more platelets to the site. The cycle of more thrombus formation and platelets aggregation continues to grow and forming more and more fragile thrombi that may break and become an …show more content…
CVI is insidious in onset due to the time it takes for the pump valves in the veins to be damaged. The diminished action of pump valves result to development of varicose veins and venous hypertension. This sequence of events doesn’t occur in DVT. DVT is rapid in reaction due to the subsequent inflammatory response and the formation of thrombus. The etiology is mostly related to immobility, hypercoagulable states and inherited abnormalities such as factor prothrombin mutation ,V Leiden mutation , deficiencies of protein C and S, and antithrombin deficiency. In most cases, DVT lacks any visual representation of symptoms due to it occurring deep in the

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