Calorimetry

Levofloxacin cocrystals were prepared by solvent evaporation method. The drug and co formers, stearic acid and sodium saccharin were physically mixed in varying ratios of 1:1, 1:3, 1:5, 1:7 and 1:1 and 2:1 respectively in a glass mortar and the mixtures were dissolved in ethanol as solvent for crystallization. The solvent evaporation was carried in rotary flash evaporator (Laborota 4000, Hiedolph) maintained at 40 ± 2ºC and speed of 30 rpm. The products obtained were dried in a desiccator and…

identifies heat and works as a method of transferring energy, which brings a change in the internal energy of a photon. Heat can also be described as the change in temperature either increasing (hot) or temperature decreasing (cold). Along with heat, calorimetry is the study of science associated with the determination of the changes of energy in a system by measuring the heat exchanged with its surrounding. And to find the exchange of heat from one object to another you have to use a…

carboxylesterases 17 , etc. Since Pks13-TE contains serine as the nucleophile in the catalytic site, FAPs can be tested against Pks13-TE. Aim 2: Characterize the inhibitory activity of thiophene compounds against Pks13-TE using Isothermal Titration Calorimetry Zhang, W et al. has Recently shown that thiophene compounds are expected to form non-covalent interactions with Pks13-TE 18. The 4MH-based assay, which is explained in aim 1 will be used to assess the thiophenes inhibitory activity of…

At Middle Tennessee State University student looking to pursue a forensic science major is required to earn 120 credit hours to graduate with a forensic science degree. According to the Forensic Science Academic Map, found in the Forensic science section on the MTSU website, as a freshman, a student must earn 29 credit hours of Expository Writing and Research and Argumentative Writing which focus on a variety of analytical writing and utilizing resources for the purpose of research. General…

Chips are often put in the unhealthy food category, chip brands like Doritos are known for their festive, decadent flavors but are loaded with calories. The calorie count in a bag of white corn tortilla chips is 1,041 according to the USDA. Doritos are flavored tortilla chips that are covered in a powder seasoning. One ounce of Doritos® JACKED™ Ranch Dipped Hot Wings Flavored Tortilla chips is 130 calories. According to Christian Nordqvist's article in Medical News Today, a calorie is a unit of…

CRISPR stand for: Clustered Regularly Interspaced Short Palindromic Repeat. The CRISPR is repeat spacer array contain a series of short direct repeats interspaced with short sequence which had been detected in the genome of many bacteria and archaea. The CRISPR method is based on the natural defense system used by bacteria to protect themselves from invading viruses. When the DNA of virus detected by bacterium, the CRISPR RNA as a guide RNA which contain a sequence, match to the invading virus…

The main objective of the experiment was to determine the effect of temperature the mass specific metabolic rate (MR_MS) through oxygen consumption, if their body weight had an effect on mass specific metabolic rate and if the size/mass of the female swiss mice affected their response to the temperature. The different mice were placed within a plastic chamber and then placed in different variations of temperature of water (10°C, 15°C, 20°C, 25°C, 30°C). The procedure involved acclimating the…

This lab was conducted to find the key differences between the quantity of heat (q) and ∆H of a substance. Different masses of substances CaCl2 and NH4NO3 were dissolved in water to see how changing mass impacts the q and ∆H of a substance. When the two substances dissolve, they become ions. CaCl2 dissolves in a reaction of: CaCl2 Ca2+aq + 2Cl1-aq while NH4NO3 dissolve in a reaction of: NH4NO3 NH41+aq + NO31-aq . As shown in these reactions, when ionic compounds dissolve in water, they break…

The crystal size is also affected by the rate of cooling and larger crystals were shown to be formed when fat was cooled at a slower cooling rate83. However the samples were not subjected to changes in the rate of cooling in this study. At higher temperatures (or lower supercooling conditions) due to decrease in the driving force, less crystals are formed although the crystals are larger in size as compared to those formed at lower temperatures83. At lower temperatures, due to the higher driving…

Styrene (St, 99%) and methyl methacrylate (MMA, 99%) were obtained from Aldrich company. These monomers were first dried over calcium hydride, were purified by being passed through a column of basic alumina, and were distilled under reduced pressure. Ethyl 2-bromoisobutyrate (EBIB, 98%), copper (I) bromide (CuBr, 99%), copper (I) chloride (CuCl, 99%), and other chemical reagents were procured from Aldrich company and used as received. N-methylbis[2-(dodecylthio)ethyl]amine (SNS) was synthesized…