Amyloid

before getting diagnosis. There are five stages of Alzheimer’s disease; preclinical, mild cognitive impairment, mild dementia, moderate dementia, and severe dementia. Preclinical can last for years without symptoms but mew technologies can show the amyloid beta (Alzheimer’s Trademark) proteins. Mild cognitive impairment shows a slight change in memory and thinking. Mild dementia has easily picked out symptoms, from loss of memory to getting lost. Moderate dementia, people grow confuse and…

The neurodegenerative diseases, or dementias, are characterized by progressive and irreversible degeneration of the neurons from specific regions of the brain. The pattern of neuronal loss is selective and compromises one or more groups of neurons, without affecting the others. An interesting aspect of these dementias is them arise without any apparent triggering stimulus and in patients with no history of neurological deficits. Alzheimer’s disease is the most prominent of these dementias,…

impairment among the elderly (Ott et al. 1995). AD is a progressive neurodegenerative disorder, primarily characterized by neuronal loss, formation of intraneuronal neurofibrillary tangles (NFTs) and accumulation of β-amyloid peptides (Aβ), as plaques in brain parenchyma or as cerebral amyloid angiopathy (CAA) in blood vessels (Reitz and Mayeux 2014). Additionally, structural brain abnormalities, blood-brain-barrier (BBB) dysfunction, brain atrophy, and neuroinflammation have been associated…

plaques littering the brain like shrapnel between neurons. The plaques consist of extracellular aggregations of beta-amyloid peptide, which is cut from a normal membrane precursor protein by enzymes” (464). As stated by Marieb and Hoehn (2016) “One form of Alzheimer's disease is caused by an inherited mutation in the gene for APP (precursor molecule), suggests that too much beta-amyloid may be toxic” (464). One of the many forms that can be found to be a factor. There are several different…

Ronald Reagan was diagnosed with Alzheimer 's disease in 1994, which was after his presidential term. Alzheimer 's disease (AD) is an incurable and debilitating chronic progressive neurodegenerative disorder which is the leading cause of dementia worldwide (Kazim and Iqbal, 2016). Many of Reagan’s speech characteristics changed and can be associated with the neurological structures such as the myelination of the neurons as well as specific genes and the thickness of the surrounding cells of the…

Alzheimer’s disease is the most common form of dementia. Dementia is a cognitive disorder with two forms: neurodegenerative and vascular disorders. Neurodegenerative is a deterioration of the mind and vascular disorders are caused by a decreased blood supply to the brain.(Lewis et al., 2014, p. 1444) With Alzheimer’s disease, the brain starts to change with age and brain transmitters start to get covered with plaque, get tangled, louse connections, and cause death in some transmitters. These…

Alzheimer's is a debilitating brain condition that impairs the memories of anyone afflicted with it. This disease begins as something simple as remembering current events. However if you can not remember something that recently happened do not diagnose yourself with Alzheimer’s. As Alzheimer’s progresses it causes trouble focusing and doing daily actions. Confusion or frustration when doing simple tasks, extreme mood swings, disorientation and trouble communicating are all signs of…

hydrophobic and aggregate or clump together, causing amyloid plaques or fibers to form. (https://www.chem.wisc.edu/deptfiles/genchem/netorial/modules/biomolecules/modules/protein1/prot13.htm). This causes neuronal death, affecting the central nervous system and eventually leading to brain death…

Inclusion Body Myositis is a neuro-muscular disease affecting people over fifty, mostly males, is characterized by progressive muscle weakness and atrophy in key muscles in the arms (forearm flexors) and the legs (quadriceps), resulting in severe disability. IBM is generally a slowly progressive disease and life expectancy isn’t significantly affected. Ted was diagnosed with IBM in 2012 when he was 68 years old, but his muscle biopsy showed that he has had it 10 to 15 years prior to the…

As a Colorado native, I spent much time in the mountains, hiking, skiing, camping, and I've developed an admiration for nature. Of my family, I’m the most skilled at spotting wildlife, from brown bears in the neighborhood, tadpoles in ponds, monk seals on beaches (when my mother was convinced it was a rock), to eagles on trees, I've always paid attention to the creatures around me. Eventually in freshman year I began to seriously study the sciences, and the capabilities of applying them. For a…