Amyloid

other disease. Pathophysiology The ultimate cause of Alzheimer’s is currently unknown, but there are two basic problems that scientists think cause Alzheimer’s to develop. The first problem is plaques. Plaques are clumps of protein called beta amyloid. The plaques damage and destroy brain cells, sometimes interfering…

A-beta (Aβ) peptide is derived from amyloid precursor protein (APP) which is a transmembrane protein with a 590-680 amino acid long extracellular amino terminal domain and an approximately 55 amino acid long cytoplasmic tail which contains intracellular trafficking signals. mRNA from the APP…

Alzheimers Alzheimer’s, one of the incurable disease affecting hundreds of thousands of people each year. Alzheimer’s is a progressive disease of the brain that slowly causes impairment in memory and other cognitive functions. But how and why does it happen, and can it be cured? Scientist are learning more and more each day about Alzheimer’s and learning more to find a cure for the incurable disease. Also, some people might relate Dementia to Alzheimer’s but they are different things. Dementia…

hypothesized that due to the third copy of chromosome 21 in all cells particularly the amyloid precursor protein (APP) could be part of the connection to Alzheimer’s disease being so prevalent in individuals with Down syndrome even though scientists are not clear on all of the functions of APP. It is noted in an article on the Alzheimer’s Association website “One of the brain’s APP processing pathways produces beta-amyloid, a fragment that’s the chief component of plaques and a prime suspect in…

dementia due to the neurodegenerative process which involves deposits of protein known as amyloid in neurons and neurofibrillary tangles which form plaques. This formation of plaques leads to neuron death and the hardening of tissue leads to progressive and terminal neurological disease state. There has been no cure to Alzheimer’s disease to the complexity of disease and the lack of understanding of amyloid protein and its process. Mild cognitive…

Alzheimer’s disease (AD) is a devastating neurodegenerative disease characterized by the accumulation of amyloid beta (Aβ) peptides within the brain. The buildup of amyloid plaques in the AD brain disrupts synaptic functions, leading to progressive neuronal degeneration, culminating in the death of the AD patient within ten years of diagnosis. As of writing this letter, no treatment exists that is capable of impeding AD progression. However, Dr. Carter’s hypothesis that increasing apolipoprotein…

the brain, there is a build-up of a protein called beta-amyloid. As a result, some plaques are found in between dying cell inside of the brain. The tangles are in the neurons of the brain as an effect of breakdown of another protein called tau. The cell death occurs because of the death of mitochondria. Mitochondria produce energy needed for any cell to function and survive. In Alzheimer’s disease, the abnormally high amount of beta-amyloid damage brain mitochondria which leads to the neuronal…

A look at Alzheimer’s disease One of the things that terrify people the most about aging is no remembering your loved ones or forgetting the great adventures you had in your youth. Unfortunately there are many cases of people who establish a disease called Alzheimer’s disease. Alzheimer’s is taking the lives of many people and directly affecting their families. People who have never heard of Alzheimer’s have many questions, they want to know what Alzheimer’s is , what causes it,…

that gradually deteriorate until their death. An important concept will be to understand what happens in the brain before the disease becomes severe. According to Stahl, (2013) the AD in mind from toxic AB peptides, which lead to the deposition of amyloid plaques in the brain; that end up destroying neurons which spread all over the brain. Some…

The APOE gene, located on chromosome 19, is a gene that helps in the creation of apolipoprotein E to help to form molecules called lipoproteins, this protein forms the lipo-proteins by combining with lipids in the body. By forming lipo-proteins, apolipoprotein E participates in the responsibility of managing cholesterol and carrying it, and other fats, through the bloodstream. By maintaining cholesterol, it helps to act as a prevention against disorders that can hurt the cardiovascular system,…