Proteomics

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  • Mixed Protein Solution For Pancreatic Cancer

    and physical symptoms (jaundice, abdominal pain, and weight loss) do not present until the cancer is in its later stages. As a result, the best way of treating pancreatic cancer is to detect and treat it in its early stages. With that being said, there have been no real advances in the early detection of pancreatic cancer. Most current methods of detection, such as biopsies, are too invasive and costly. However, recent research has shown that proteomic analysis of saliva can be used to identify the progression of certain systemic cancers. More specifically, differences in the protein composition of saliva of patients with lung cancer and healthy individuals have been shown to predict the progression of malignant cells. By applying these same principles to the diagnosis of pancreatic cancer, this experiment aims to identify protein biomarkers that can potentially be used in the early detection of the cancer. In order to identify possible biomarkers for the diagnosis of pancreatic cancer, this experiment will employ a variety of proteomic techniques. First, salivary samples will be collected from volunteers with and without pancreatic cancer. The protein concentration for each individual sample will then be determined by bichinchoninic (BCA) assay. BCA assay is used to determine protein concentration by measuring the amount of reduced cuprous ions that are generated by chelating copper with proteins in the sample. The reduced cuprous ion then reacts with BCA, forming a…

    Words: 1330 - Pages: 6
  • Proteomic Organization Of Co-Mmad And I-Smads Case Study

    Figure 2. The proteomic organization of three subfamilies of Smads (Co-Smad, R-Smad and I-Smad) and organization of a Smad MH1 domain with DNA. (A) All Smads information taken from PDB entry Smad>UniProt Gene list of Smads. The conserved N-terminal MH1 domain is in red, linker region in dark blue and the C-terminal MH2 domain in deep yellow. In the linker region the red PXS/TP (or S/TP) indicates the potential phosphorylation site for MAPKs ERK1/2, and the square indicates the PY…

    Words: 931 - Pages: 4
  • Mass Spectrometry Lab Report

    Introduction: One of the most common mass spectrometry–based proteomic methodologies used to day is the bottom up protein identification. First, the protein has to be digested into peptides using a protease. Then, the peptide will be submitted to the URMC Proteomics Resource and Laboratory for analysis using LC-MS/MS tandem mass spectrometry. In this approach, the peptides will be separated and introduced into a mass spectrometer using reversed phase liquid chromatography (RC-LC). This…

    Words: 824 - Pages: 4
  • Pt1420 Exercise 1

    proteins? Proteins are large, complex mole­cules made up of chains of small chemical compounds called amino acids. 6. What do proteins do? The proteins perform most life functions and even comprise the majority of cellular structures. Chemical properties that distinguish the 20 different amino acids cause the protein chains to fold up into specific three-dimensional structures that define their particular functions in the cell. 7. What determines a protein's chemistry and behavior? A…

    Words: 742 - Pages: 3
  • Lovastatin Research Paper

    perturbation of protein expression in HL-60 human acute promyelocytic leukemia cell. The aim of this study is also to observe whether lovastatin-induced down-regulation of glutamate synthetase, carbonate dehydratase II, estrogen receptor and steroid receptor RNA activator I contributes to the cytotoxic effect of lovastatin. Besides, previous studies revealed the upstream events on the inhibition of sodium/ hydrogen antiporter which were unclear. Therefore, a mass spectrometry along with SILAC…

    Words: 1599 - Pages: 7
  • Critical Appraisal Assignment Analysis

    standards of critical appraisal. Unfortunately my critical appraisal was written in a very short period of time due to being unwell, however I believe I have gained a good knowledge and understanding of how to criticise a paper. I have followed all instruction that been given for student on Canvas, to make it more straightforward. I can defiantly say that my writing skills have improved after learning how to criticise a paper. I understood importance of scientific writing and how it is going to…

    Words: 1002 - Pages: 5
  • Animal Research Application Essay

    These all relate to open challenges in metabolomics for refined the phenotypic description of cattle (1) determine key metabolic process to provide tools for improving cattle husbandry/nutrition (2) identify potential biomarkers for animal selection (3). I am already working on these three major challenges and disseminating the findings. As current work matures, I am looking forward to the opportunity to focus on these challenges and integrate with a large scale "omics" capability (genomics,…

    Words: 1206 - Pages: 5
  • Dracaena Cinnabari Case Study

    Shots/Sub-Spectrum for 500 aggregate Shots/Spectrum). The inside alignment was performed utilizing a standard calibration mix 5 (Applied Biosystems). For the MS/MS precursor selection, least S/N (signal/noise) filter was set at 25 with a prohibition list for α-Cyano-4-hydroxycinnamic acid lattice peaks. Protein identification was only considered with a statistically significant probability based Mowse score (p<0.05). Proteins with more than 2 peptides match were only considered for further…

    Words: 1296 - Pages: 6
  • Write An Essay On Why I Want To Make A Rocket

    In our time, we are living in a challenging era where the advances at molecular, genomics, proteomics and metabolomics levels, demands a pathologists as leaders of the revolution in personalized medicine and all those changes really excite me, I want to be at the first line of these amazing improvements in medicine. It would be an honour for me to pursue my career at McGill University. McGill 's anatomical pathology program shines both locally and internationally with regards to its expertise,…

    Words: 725 - Pages: 3
  • Junk Dna Thesis

    I would like to present the book chapter (leading and corresponding author) and one of my research articles (co-first author) and the as academic writing samples here. The book chapter entitled “Genomics and Proteomics in Brain Complexity in Relation to Chemically Induced PTSD” was published in Handbook of Toxicology of Chemical Warfare Agents, Second Edition edited by Dr. Ramesh C. Gupta and the research article “Regulation of the Apolipoprotein Gene Cluster by a Long Noncoding RNA” was…

    Words: 703 - Pages: 3
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