Pharmacokinetics

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  • Analysis Of Araliae Continentalis Radix

    Keywords: Aralia continetalis Kitagawa; Kaurenoic acid; Phase I; Pharmacokinetics; Ultra-performance liquid chromatography-tandem mass spectrometry Abbreviations: AIC, akaike information criteria; AUC0-∞, the area under the concentration–time curve from zero to infinity; CL/F, the total body clearance for oral administration; Cmax, the maximum plasma concentration; CV, coefficient of variation; HPLC, high-performance liquid chromatography; ka, the absorption rate constant; IS, internal standard; LLE, liquid–liquid extraction; LLOQ, lower limit of quantification; MRM, multiple reaction monitoring; PK, pharmacokinetic; QC, quality control; t1/2, the terminal half time, Tmax, the time to reach Cmax, UPLC-MS/MS, ultra-performance liquid chromatography-tandem…

    Words: 972 - Pages: 4
  • Docetaxel Solubility

    and was found to be 2.3 times lower than the pure docetaxel indicating higher cytotoxicity of docetaxel by formulating as L-SNEDDS (Fig. 9D) compared to pure docetaxel (Fig. 9C). However, blank L-SNEDDS (Fig. 9B) exhibited only non-significant cytotoxic effect and shown similar cell viability compared to non-treated control cells (Fig. 9A). The enhanced cytotoxicity of L-SNEDDS might be due to the high permeability and rapid absorption of molecularly dissolved cytotoxic drug into the cancer…

    Words: 1368 - Pages: 6
  • Female Sprague

    analysis. Tissue samples of the liver, kidney, heart, lung, and spleen were dissected and taken immediately after taking the blood sample at the terminal time (PFOA, 24 h; PFOS, 70 day; PFHxS, 336 h) and stored frozen (−80 °C) until analysis. The pharmacokinetic parameters were calculated by WinNonlin® software (version 6.4, Pharsight®, a Certara™ Company). The Cmax and the time to reach Cmax (Tmax) were determined by the visual observation of the individual plasma concentration–time profiles of…

    Words: 937 - Pages: 4
  • Pharmacokinetics Analysis

    Pharmacokinetics is the branch of pharmacology that describes how the body affects a specific drug after administration. A number of phases occur once the drug enters into contact with the gastro intestinal wall, these are described using the acronym ADME, starting with the mechanisms of absorption, which is the process by which a substance enters the blood circulation. Distribution, where the dispersion or dissemination of substances throughout the fluids and tissues of the body. ADME also…

    Words: 894 - Pages: 4
  • Pharmacokinetics Of S)-Ketoprofen Case Study

    2.3. Pharmacokinetics of (S)-ketoprofen 2.3.1. Blood sampling On the day of the study, rats were cannulated approximately 30 min before uric acid injection and 3 h before the drugs were administered. The animals were anesthetized and the caudal artery was cannulated with a PE-10 cannula (Clay Adams, Parsippany, NJ, USA) connected to a PE-50 cannula. The cannula was kept patent with heparinized saline solution and stopped with a needle. Rats were allowed to recover from anesthesia and…

    Words: 1474 - Pages: 6
  • Diagnostic Summary

    According to Edmunds (2014) pharmacokinetics is when the action of a medication in the body is study, which includes the process of absorption, distribution, metabolism and elimination (Edmunds, 2014). The patient that currently being cared for is a 73 year old female with past medical history of atrial fibrillation, kidney dysfunction and diabetes mellitus. Currently the patient takes the following medications: Pravastatin 10 mg, Lisinopril 2.5 mg, Digoxin 0.125 mg, Warfarin 7.5 mg, HCTZ 25 mg,…

    Words: 918 - Pages: 4
  • The Importance Of Clinical Monitoring

    Brahmankar D M, Jaiswal S B, (Feb-5 2009). Biopharmaceutics and Pharmacokinetics. 2nd edition, page no.315-363 Ref...9. B. Clinical Response: Clinical trials in humans establish safety and effectiveness of drug products and may be used to determine bioavailability. However, clinical trials approach is the least accurate, least sensitive, and least reproducible of the general approaches for determining in-vivo bioavailability. The FDA considers this approach only when analytical methods and…

    Words: 2578 - Pages: 11
  • Clinical Manifestation Of, And Risk Factors For Rhabdomyolysis

    This will prevent additional injury to the skeletal muscle. • Since Saskia is currently taking Enalpril for hypertension, it may need to be discontinued due to risk of kidney complications. The prescriber must ensure blood pressure if monitored during this time to ensure harmful effects do not occur. OBJECTIVE #7 – Strategies for addressing potential pharmacokinetic and pharmacodynamic drug-drug interactions in professional practice • It is important to always be aware of metabolic pathways…

    Words: 1074 - Pages: 5
  • Cabozantinib Model Analysis

    Introduction Cabozantinib, developed by Exelis Inc. as initially XL185, was first FDA approved in 2012 under the brand name CometriqTM. There are two formulations of cabozantinib in which CometriqTM is an oral capsule and has the clinical advantage of a quicker delivery time in comparison to its tablet form (CabometyxTM). Bioequivalence for the formulations are not the same, a 19% higher Cmax for the tablet form, and should not be used interchangeably. The current essay will focus on the drug…

    Words: 975 - Pages: 4
  • Echinocandins Case Study

    leads to osmotic instability and cell death. Antifungal spectrum Echinocandins display good fungicidal activities against: • Candida albicans, • Candida parapsilosis and • Candida guilliermondii. Also have activity against amphotericin B-resistant and fluconazole-resistant Candida glabrata. For Aspergillus species, echinocandins have fungistatic activity contest to amphotericin B and trizoles, which display fungicidal activity. Echinocandin resistance, though not common, has been found in C.…

    Words: 810 - Pages: 4
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