10.1 SUMMARY The aim of the present investigation was to formulate Raloxifene Hydrochloride Liquisolid compacts, with coadministration of a bioenhancer, for oral bioavailability enhancement. The reason for poor bioavailability (2%) of Raloxifene Hydrochloride is low solubility (100μg/mL) and high hepatic first pass metabolism. According to BCS, Raloxifene Hydrochloride is considered as Class II drug, lipophilic and highly permeable compound. Therefore, formulating Liquisolid Compacts bearing…
Question 1 Assess Mr Logan’s medication chart. Identify and explain three significant risks that may be associated with the use of the medicines (home or inpatient use) for Mr Logan. The total dose of parenteral digitalisation for the elderly is 25-500microgram. This may be given slowly by Intra Venous Route, single dose or divided doses each 125-250 microgram at intervals of 4-6 hours. The immediate STAT dose given at 1100 01/05 was the total dose, the prescribed post expected doses 4 hourly…
Heroin)). The majority of the morphine taken is excreted from the body within 24 hours, this drug has an elimination half-life of about 120 min. This drug is stored in the fat at times and can remain detectable long after each use. Now that the pharmacokinetics is know, what pharmacodynamics happen with this…
low price, availability, and effectiveness, methadone is appealing to health care providers for the treatment of chronic pain. Although methadone has its Pros, I believe the Cons outweigh them. Risk of overdose is high, due to its unpredictable pharmacokinetic properties, inadequate patient education, polysubstance abuse, and over prescribing by healthcare providers (Aschenbrenner,2009). The methadone problem is growing in the United States. In fact, methadone…
injection is favored for administration because only roughly 35% of the concentration of the drug remains after metabolism through oral ingestion. (National Center) b. Therapeutic window (efficacy vs. toxicity) - Toxicity can be common if dosing and pharmacokinetic are not monitored carefully. Can cause toxicity in the Central Nervous System. (Yuko Ikeda,…
It is very common to come across an older patient and for them to be on 5 or more medications. However, just because this is a common occurrence does not mean that it is acceptable. To put it in perspective an average “adult age 65 and older compose 13% of the population in the United States, yet this cohort accounts for more than one-third of overall outpatient spending on prescription medications”, which comes to show that older adults are consistently prescribed numerous medications of which…
Animal testing is known as “The use of non-human animals in research and development projects, especially for purpose of determining the safety of substances such as foods and drugs (Dictonary.com)” It is said that there are millions of vertebrae animals used in the testing such as mice, rats, birds, monkeys, dogs, cats and farm animals. Majority of the animals used in testing are either put to sleep or killed to experiment on. Last year I had some experience of my own to see this for my own…
mainly used to treat anxiety and insomnia for adults.Since anxiety and isomnia is getting more common nowadays, It is nesseary to be introduced to more people.In this article, you will know more about the clinical trial ,the pharmacology ,and the pharmacokinetics of Lorazepam. Disscussion of a clinical trial for Lorazepam Lorazepam has a good efficacy in treating patient with insomnia.According a clinical trial research conducted by Scharf & Jacoby(1982),Lorazepam was evaluated by testing 5…
diabetes do not only increase the risk of active TB, it can also mask the sign and symptoms of TB. This will delay treatment and can lead increase the risk of mortality. The physiological changes such as alter the immune system, renal function, pharmacokinetics, sensations of symptoms, and ability to accurately present symptoms need especially consideration while screening and treating this population. Alters immune system particularly can increase elderly’ risk of reactivation TB. The classical…
against influenza A although adamantanes will not be prescribed in the United States unless under very special circumstances (Zachary, 2015). Oseltamivir, Tamiflu is the drug of choice for influenza. 3. What are the dosage ranges, action, use, pharmacokinetics, pharmacodynamics, drug-to-drug interactions, drug to herbal or food interactions, contraindications, adverse effects, guidelines for administration, and patient teaching for the administration of antiviral agents? The dosage ranges…