Huntingtin

Neurodegenerative diseases are distinguished by progressive neuronal cell loss with clear patterns in disparate disorders such as Alzheimer’s, Parkinson and Huntington’s. They are responsible for around 4% of fatalities worldwide and 5% of disability-adjusted life years from a non-communicable disease (NCD). Neurodegenerative disorders are not only caused by genetics but protein misfolding disorders and protein degradation by the proteasome system. These disorders continue to increase as well as…

Huntington's disease is caused by a expanding mutation to the DNA code. This disease affects about one out of ten thousand. People with this disease have a fifty to fifty chance of passing it on to their children. The symptoms start from ages thirty to fifty. Six percent of people that carry this disease can get Juvenile Huntington's Disease which affects kids and teenagers. Most patients die about ten to twenty years after symptoms begin. Huntington's Disease is a neurodegenerative disease…

The disease is caused by the expansion of a polyQ segment located within the first exon of the gene encoding huntingtin, an 350-kDa protein. The neuronal inclusions in HD have fibrillar morphology and contain aggregated amino-terminal fragments of huntingtin . Similar inclusions containing aggregated polyQ proteins were reported in other polyQ diseases.(1,2)Previous studies have shown that two process namely the autophagy and the proteasomal…

The normal form of Huntingtin gene (Htt) contains 6-35 glutamine residues. HDAC3, abundantly expresses in the brain, directly binds to it with this short polyglutamine (pQ) and this interaction normalizes the intrinsic neurotoxic property of HDAC3. With long pQ Htt, the interaction…

HUNTINGTON’S DISEASE Huntington’s Disease is a primarily mental disease that has many different symptoms. Though the disease does mainly affect the mind and the brain, there are many physical effects that accompany it. The disease was first described by George Huntington in the late 1800s, however any further advancements in knowledge of the disease didn’t come until much later. People affected by this disease are affected in many different ways, and at many different times in their lives.…

http://www.mayoclinic.org/diseases-conditions/huntingtons-disease/basics/definition/con-20030685 http://www.hdsa.org http://www.alz.org/dementia/huntingtons-disease-symptoms.asp http://www.asha.org/public/speech/disorders/HuntingtonsDisease.htm http://www.brainfacts.org/diseases-disorders/degenerative-disorders/articles/2012/huntingtons-disease/ Huntington's disease-also referred to as "HD"- is a hereditary brain disorder that causes the progressive…

Huntington’s Disease Huntington’s disease is a disease that causes parts of the brain to break down; degenerate. This disease doesn’t show it’s symptoms between the ages 30 and 50. The gene name is HTT, the official name is huntingtin. HTT belongs to the family called endogenous ligands. It’s passed from one generation to the next, the size of CAG trinucleotide repeat often increase in size. A larger number of repeats is usually associated with an earlier onset of signs and symptoms. This…

describing a disorder which later became known as Huntington’s Chorea (Huntington’s New South Wales). The exact gene was not discovered, however, until 1993. The Huntington Disease gene is a mutation on the fourth chromosome, which codes for the protein huntingtin (“Learning About Huntington’s Disease). The defective gene contains repeating segments of CAG. Normally this section of DNA is repeated 10 to 28 times. A HD gene can repeat this specific section 36-120 times. The amount of times the…

Huntington’s disease Huntington’s disease, found within Cellular and Molecular Biology, is a fatal genetic disorder that causes progressive breakdown of nerve cells in the brain. It is a rare autosomal dominant progressive neurodegenerative disease. In this essay, Huntington’s disease will be discussed in reference to the biology behind the faulty HTT gene, the signs and symptoms associated with the disease, along with coping mechanisms and outcomes for those suffering from the disorder.…

Huntington’s Disease Huntington’s Disease is a disease that takes place in the brain due to the loss of brain cells, It is uncommon amongst most populations but might even affect you. Huntington’s disease is a genetic defect in the process of making proteins. It is an unusual Mutation that causes the loss of Neurons which are brain cells. It was discovered by an American doctor in the 1872. The disease is described in many names including “Huntington’s Chorea”. It is inherited from parents. It…