Epigenetics

DPP4 is also known as CD26; ADABP; ADCP2; TP103 is a transmembrane glycoprotein of 110 kDa (DPP IV, EC3.4.14.5) that forms a homodimer or tetramer, which is ubiquitously expressed on the surface of a variety of cells particularly the kidney, liver, small intestine, and in a soluble form in plasma. This exopeptidase serine protease selectively cleaves L-proline or L-alanine at N-¬terminal dipeptides and inactivates the biologically active peptides from a variety of substrates including…

concentration in Psychology, I believe the clinical internship is an ideal blend of my past academic, laboratory and extracurricular experiences. As an undergraduate research assistant at the Champagne Laboratory, which specializes in psychobiology, epigenetics and neuroscience, I’ve independently studied the gene expression and methylation profile of adult mice exposed to early-life maternal separation. In choosing the depression and anxiety target genes for my study, I’ve been exposed to a…

Mental illness has been a hot topic in recent news. From Sandy Hook to the Aurora movie theatre shooting, effects of mental illness has sparked fierce debate and a negative stigma surrounding the issue. However, only 59.6% of individuals with a mental illness report receiving treatment, as often those with mental disorders are seen as “dangerous, unpredictable, responsible for their illness, or incompetent” (Corrigan, Druss, and Perlick). With so much riding on the issue, a question needs to be…

Marriage is a concept older than any society or religion. It has gone through many changes through history and across the world. The idea of what defines a marriage has really heated up during the 20th century. In the late 60’s there was some scuttles with the police and gay areas in Ontario and New York. These started to lay a foundation down of what right a government has to interfere with a group of people that are causing no harm Through the 70 's the HIV/AIDS crisis came unfolding many…

Introduction So what is GGT? GGT stands for Gamma-glutamyl Transferase, it is found on the cell surface that contribute to the extracellular catabolism of glutathione (GSH). The most GGT serum is derived from the liver, but it is also produced in many other tissues. GGT is primarily carried with lipoproteins and albumin in serum. The levels of GGT is determined by various factors such as alcohol intake, body fat content, plasma lipid/ lipoproteins and glucose levels, and also various medications…

reduction and also in a few instances cost savings are also pointed out. Geographical and historical aspects of touch therapies have been woven into this Literature Review in order to spotlight cultural influence as well as the time period which they begin, dating back to the origination of reiki in Tibet over 3000 years ago (Wardell and Engelbreston, 2001, p.440). Chapter III is the Methods Chapter which is similar to a blueprint, meaning that another researcher should be able to duplicate this…

Alternatively, inflammation-induced activation of the pro-tumor cytokine family causes epigenetic modifications. A persistent inflammatory response in individuals with ulcerative colitis and inflammatory bowel disease causing oxidative stress and activation of TNF-α and NF-ҡB (tumor promoting cytokines) has been suggested as a major cause for colorectal cancer (Kraus et al., 2009). Activation of cytokines like STAT3 and NF-ҡB can also induce stem cell-like phenotype and stem cell expansion in…

Nucleosomes and histone are put together to make chromatin. When the structure of chromatin changes, it affects gene expression. This leads to epigenetics patterns of DNA methylation and histone modifications. Alternations of these patterns cause change in the regulation of gene expression. After these changes in gene expression, the results are an epigenetic cause of disease because of the loss of normal DNA methylation. (Mann & Rodenhiser,…

than three, and be specific.) I take great pride in being acknowledged in a recent Nature scientific journal publication entitled “Epigenetic Editing of Ascl1 gene in Neural Stem Cells by Optogenetics,” which stems from my work as a research intern at the Indiana University School of Medicine. I am also proud to have had the opportunity to present my research work as a semi-finalist at the Armed Forces-sponsored Southern California Junior Sciences and Humanities Symposium. Last but not least, I…

Chromosomes, or strings of genes carrying genetic information, are vital to the existence of living things. A specimen cannot have more or less than how many that particular species needs. In humans, this number is 23. The 23rd pair of chromosomes, referred to as Group X, contain the sex cells that decide the gender of the organism. If a Y chromosome is present, the organism is male, and if not, it is a female. If the chromosomes fail to separate correctly during meiosis (type of cell division…