DPP4 is also known as CD26; ADABP; ADCP2; TP103 is a transmembrane glycoprotein of 110 kDa (DPP IV, EC3.4.14.5) that forms a homodimer or tetramer, which is ubiquitously expressed on the surface of a variety of cells particularly the kidney, liver, small intestine, and in a soluble form in plasma. This exopeptidase serine protease selectively cleaves L-proline or L-alanine at N-¬terminal dipeptides and inactivates the biologically active peptides from a variety of substrates including cytokines, growth factors, neuropeptides, glucagon- like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) and incretin hormones. Also DPP4 is a novel adipokine released from differentiated human adipocytes and it may exert autocrine
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PCOS is characterized by hormonal imbalance, hirsutism, amenorrhea, chronic oligo- anovulation, and morphologically abnormal ovaries with numerous small follicular cysts (Banaszewska et al. 2006). PCOS show an increased prevalence of hyperandrogenism, obesity, insulin resistance and diabetes. Thirty-eight to 88% of women with PCOS are overweight or obese (Balen, A. H. 1995; Legro, R. S. 2000). Hyperandrogenism in PCOS patients influences the pathophysiology of adipose tissue, because excess androgen facilitates the deposition of abdominal visceral fat in human and animal models (Xita and Tsatsoulis, 2006). Adipose tissue is considered as an active endocrine organ that secretes hormones, growth factors, cytokines, adipokines and other molecules, and also participates in a large number of physiological processes that are involved in the maintenance of energy homeostasis of the body (Rosenbaum et al., 1997). DPP4 is a novel adipokine released from differentiated visceral or omental (OM) human adipocytes. A little is known about the associations between fasting plasma CD26/DPP-IV levels, metabolic disorders, and T2DM. In addition, the associations between plasma CD26/DPP-IV levels in PCOD patients either with or without MetS are still
PCOS is characterized by hormonal imbalance, hirsutism, amenorrhea, chronic oligo- anovulation, and morphologically abnormal ovaries with numerous small follicular cysts (Banaszewska et al. 2006). PCOS show an increased prevalence of hyperandrogenism, obesity, insulin resistance and diabetes. Thirty-eight to 88% of women with PCOS are overweight or obese (Balen, A. H. 1995; Legro, R. S. 2000). Hyperandrogenism in PCOS patients influences the pathophysiology of adipose tissue, because excess androgen facilitates the deposition of abdominal visceral fat in human and animal models (Xita and Tsatsoulis, 2006). Adipose tissue is considered as an active endocrine organ that secretes hormones, growth factors, cytokines, adipokines and other molecules, and also participates in a large number of physiological processes that are involved in the maintenance of energy homeostasis of the body (Rosenbaum et al., 1997). DPP4 is a novel adipokine released from differentiated visceral or omental (OM) human adipocytes. A little is known about the associations between fasting plasma CD26/DPP-IV levels, metabolic disorders, and T2DM. In addition, the associations between plasma CD26/DPP-IV levels in PCOD patients either with or without MetS are still