Coagulation

Why is Sharon is experiencing the following signs/symptoms? Please provide the specific pathophysiology. (4 points) •Jaundice: Jaundice occurs when your liver doesn’t metabolize bilirubin the way it’s supposed to. Accumulation of bilirubin or its conjugates in body tissues produces jaundice, which is characterized by high plasma bilirubin levels and deposition of yellow bilirubin pigments in the skin and other tissues. Jaundice caused during the hepatic phase can arise from abnormalities in the…

Haemophilia A. Blood clotting requires certain types of clotting factors. Haemophilia patients however lack the clotting factor type V111. This is caused by inversion mutations at Xq28. As a result of this mutation, patients have very slow rate of blood coagulation. Hence they suffer from prolonged internal and external bleeding at various instances. Nosebleeds and blood in urine and stools is also common among victims. When internal bleeding occurs at joints it causes joint aches and…

Lassen et al. (2009) aimed to demonstrate that Apixaban at a dose of 2.5mg twice daily is just as safe and effective as enoxaparin when administered at a dose of 30mg subcutaneously every 12 hours. While Lassen et al. (2010a) observed Apixaban at the same dose but against enoxaparin 40mg once daily. The treatment period for both studies lasted between 10-14 days. The primary efficacy outcome for the above mentioned studies included the following scenarios; symptomatic or non-symptomatic DVT,…

Electrosurgery is the passage of high frequency electrical current through the body to achieve a desired surgical effect. The surgical effect can be achieved by, cutting, coagulating or fulgurating. The techniques of electrosurgery use today were developed in the early part of the 20th century; however, the history of the technique goes back as far as the early 19th Century. The French Physicist Becquerel was the first to demonstrate electrocautery, using electricity to heat a wire needle. Later…

Vasoplegic syndrome (VS) is a well-known form of vasodilatory shock that occurs in up to 44% of patients after cardiac surgery employing cardiopulmonary bypass (CPB)(1). CPB is often associated with a systemic inflammatory response and transient vascular dysfunction that results in profound and persistent vasodilation, leading to a decrease in systemic vascular resistance that grounds severe hypotension refractory to proper fluid resuscitation, and an increased requirement for vasopressors…

phase : which is the primary hemostasis by vasoconstriction of the arteries and vein injured. Platelet Phase: aggregation and stabilization of a hemostatic platelet on the site of injury. Coagulation phase (secondary hemostasis): Activation of Coagulation factors within intrinsic or extrinsic pathway . Types of bleeding: The 1st type bleeding that occurs several hours after the Extraction is called reactionary hemorrhage.…

accumulation of fatty deposits on the inner linings of arteries. Although coronary artery disease has also some non-atherogenic forms (e.g. arteritis, congenital coronary artery anomalies, embolism of coronary arteries, spasm of arteries or diseases of coagulation system), almost all myocardial infarctions develop from coronary atherosclerosis, generally with superimposed coronary thrombosis. [4]. During the evolution of atherosclerotic plaques, especially vulnerable (lipid-laden) plaques, a…

subject is healthy enough to participate in this study for example if their sugar levels are high then the subject may be pre-diabetic and unsuitable for this study. Also, the platelet count is important to measure due to its involvement in the coagulation cascade1. 6. Subjects will undergo ECG, echocardiogram, stress tests and an ultrasound scan to assess cardiovascular health. 7. Personal and family medical history will be…

As it was demonstrated in Figure 2, the peaks at 1703 and 1727 cm-1 in the MPS-comprising nanohybrids appeared, while the peak at 1745 cm-1 vanished. Through the formation of MPS-comprising nanohybrids, the observation of the new absorption bands (1707 and 1727 cm-1 ) concomitant of the absorption at 1733 cm-1 may be owing to the formation of ester groups through the reaction between carboxylic acid groups of PAA oligomers and silanol groups of silica moieties 12. Besides, in SiO2/PAA hybrids,…

Alkalinity is a measure of the ability of a water to resist changes in pH. Alkalinity in water is due to the presence of weak acid systems that consume by hydrogen ion produced by other reactions, allowing chemical or biological activities to take place within a water without changing the pH (1). In this way the alkalinity protects aquatic life. The measured value may vary considerably with the end-point pH used. Alkalinity is a measure of an aggregate property of water and can be interpreted…