Alpha helix

Linus Pauling was awarded the Nobel Prize in chemistry 1954 "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances"1 however he made significant discoveries in many areas of chemistry including physical and biochemistry. He also made several contributions to both theoretical and applied science from genetic diseases to diagnostic technology.2 Professor G. Hägg, member of the Nobel Committee for Chemistry stated in 1954…

Protein structure prediction is that the prediction of the three-dimensional structure of a protein from its organic compound sequence — that's, the prediction of its folding and its secondary, tertiary, and quaternary structure from its primary structure. Structure prediction is essentially totally different from the inverse downside of protein style. protein structure prediction is one among the foremost necessary goals pursued by bioinformatics and theoretical chemistry; it's extremely…

Protein aggregation is the process whereby proteins are misfolded. It is a phenomena that has been widely discussed in the scientific community over the recent years as it can lead to detrimental effects on our health such as neurodegenerative diseases. In this essay, I will be discussing the structure of a protein, its role in the human body as well as protein aggregation and the negative consequences it has on our health. Proteins are large molecules, also known as polypeptide chains which are…

development. The Protein Data Bank has a total of 114,080 deposited structures according to their Current Holdings Breakdown (1). The PDB currently holds a data entry for a protein structure with the ID, 1NWK. This is a monomeric actin protein found in alpha skeletal muscle. Actin is significant…

Cellular Respiration takes place on the level of the cell, inside the mitochondria. This is the process of breaking down food in the presence of oxygen to form ATP. ATP stands for Adenosine Triphosphate which is an energy bearing molecule found in all living cells1. Things such as bacteria can perform this with their outer membranes. When a person runs, they use cellular respiration to create energy in the form of ATP which allows their muscles to move. Many other energy-consuming reactions of…

has a unique structure, made up of a double helix, base pairing, and hydrogen bonding, all working together to make it stable. The double helix is made up of a phosphate backbone. These phosphates create a bond between the sugars and themselves,…

Q1) What secondary structures make up the large C-terminal domain of the Klenow fragment? Answer: The large C-terminal domain contains a six-stranded antiparallel β-sheet at the bottom of the cleft region and contains three α-helices on one side and four α-helices on the other side of the cleft region. Q2) Describe the three-dimensional structure of the large C-terminal domain of the Klenow fragment? Answer: The large C-terminal domain contains a significantly deep cleft, with a considerable…

Primary structure is the unique sequence of amino acids that each protein has. The secondary structure takes the polypeptide (many amino acids bonded together) that has formed and folds or coils it into a sheet or alpha helix. The tertiary stage is when the overall 3d shape of the polypeptide is formed. The final stage is quaternary, and that is when two or more polypeptides interlace. An example of a protein is transthyretin, an important transport protein. Another…

Write an essay on the structure of proteins, emphasising the forces that sustain their three dimensional structures. Introduction MORE Proteins are nitrogenous organic macromolecules constructed from a base sequence of 20 amino acids at the ribosome in cells. There are over 100,000 different proteins encoded by thousands of different genes within the human body. They all perform different functions e.g. antibodies providing immunity and enzymes catalysing metabolic reactions. The…

Proteins are large, complex molecules found throughout the body. They are polymers made out of different types of small unites called amino acids. Each amino acid consists of a central carbon atom, which is attached to a hydrogen atom, an amino group, a carboxyl group, and a unique side chain or R group. There are twenty different types of amino acids and each one of them has different chemical properties. Amino acids are held together by covalent peptide bonds therefore the proteins, chains of…