Histidine

Corynebacterium diphtheria targets cells of the mucosa membranes of the upper respiratory tract and cutaneous tissues of the skin. Rarely, infection can occur at other mucosal sites such as the eyes, ears, or genitals (CDC, 2016). C. diphtheria bacteria produce an exotoxin, diphtheria toxin, and release it to their external environment at the site of infection. From there, the toxin can travel through the bloodstream and affect different cells throughout the body, and block their protein…

commonly found as tetramer made up of two heavy and two light subunits. The heavy subunit containing the active site contains a conserved pair of copper-binding sites referred to as Cu(A) and Cu(B) which are coordinately bonded to a distinct set of 3 histidine residues His87, His108, His117 and His239, His243, His273 respectively. The identified tyro isoezymes α, β, γ, and δ, have different amino acid sequences but the same binuclear three copper center. Tyrosinase can exist latent state known…

FOOD OF ANIMAL ORIGIN 1. Dipeptides derived from β-alanine and histidine, like carnosine and its methylated analogues anserine and balenine that are widely distributed in the heart, tissues and the central nervous system of Vertebrates are analysed using HILIC separation method. This analysis used the matrix meat and…

maintain healthy joints and connective tissues. Based on their experiments, the eggshell didn’t exhibit cytotoxic effects at the dose of 100 μg in an in vitro human cell viability assay, genotoxic effects in an in vitro assay of four strains of histidine-dependent Salmonella typhimurium and one strain of tryptophan-dependent Escherichia coli at a dose of up to 5000 μg, and acute toxicity when it was tested in rats at a single oral dose of up to 2000 mg/kg body weight, nor signs of toxicity. The…

A. Introduction Imagine yourself living with a medical condition that restricts you from eating certain foods that are rich in iron and foods that increase the absorption of iron. While it is impossible to completely avoid iron in your diet, even moderate amounts can be fatal in the long run, because your body absorbs more iron from the food that you eat than most people. For many years, hemochromatosis has been a mystery to medicine, and scientists all over the world have investigated the…

Abstract: A simple, novel, and sensitive method developed for estimation of Dappagliflozin and Saxagliptin. The method was carried out on reverse- phase C18 inertsil column, with mixture of Methanol: Water ( 80:20) ratio as a mobile phase, 1 ml / min flow rate. Different analytical parameters such as linearity, precision, accuracy, Limit of detection (LOD), Limit of Quantification (LOQ), robustness were determined according to the International conference on Harmonization ICH guidelines. The…

The rise of renewable energy has unsurprisingly coincided with a greater focus on renewable energy research within the scientific community. Among the many researched, the fuel ethanol industry has taken off in recent years, and is only going to increase. But an urgent problem facing the industry is meeting the increasing demands, while dealing with detrimental losses of ethanol due to contamination. This contamination is predominantly caused by lactic acid bacteria. The lactic acid bacteria…

mucilage, pectin and hemicellulose. Fenugreek endosperm is abundant source of proteins (43.8 g/100 g) such as lecithin, globulin, and albumin. Among proteins it has a high proportion of free amino acids (20–30%), particularly 4-hydroxyisoleucine and histidine, which may stimulate insulin activity. Seeds also contain 5.5–7.5g/100g lipids in total mainly comprised of neutral lipids (85%), phospholipids (10%) and glycolipids (5%). Seeds are also a good source of essential fatty acids constitute of…

detecting large amounts of targeted proteins (Kaplow et al., 2009). GFP tagging can aid in the analysis of protein geography, movement and chemistry in a living cell (Lippincott-Schwartz and Patterson, 2003). A His-tag is a sequence of approximately six histidine residues that is usually attached to either the N- or C- terminus of the protein being targeted (Loughran and Walls, 2010). The purification process usually uses immobilized metal affinity chromatography (IMAC) (Kaplow et al., 2009). In…

Muckle-Wells syndrome (MWS) is a rare genetic disorder that causes hive-like skin rashes, chills, fever, partial or total hearing loss, swollen joints, loss of kidney function, and can eventually lead to amyloidosis in some patients. Muckle-Wells syndrome is named after Thomas J. Muckle and Michael V. Wells who first described the disease in April of 1962 [1]. Muckle-Wells is in a family of diseases called Cryopyrin-Associated Autoinflammatory Syndromes (CAPS) which all are related because they…