Our logic for choosing kinesin for developing CNS therapeutics is based upon our own research, which found that kinesins are transcriptionally upregulated during memory storage and that they are both necessary and sufficient to induce long-term memory storage (LTM) in the marine snail, Aplysia californica (Puthanveettil et al., 2008; Fig 1). Furthermore, other researchers have also discovered that an increase in specific kinesin function in the mouse forebrain improves working memory (Wong et al…
mechanisms in the brain that underlie learning and memory processes. Indeed, induction of LTP is observed coincidently with learning events in the hippocampus of free-moving animals and this learning-induced LTP occludes subsequent electrical induction of LTP in the hippocampus (Whitlock et al., 2006). Conversely, saturation of LTP in the hippocampus interferes with spatial memory formation (Barnes et al., 1994). A recent work demonstrates that in vivo artificial induction of LTD impaired recall…
research as seen in table 5, 8, 9, 10, 11 and 12. The four main structures, which form the neural circuitry of stress, involved in PTSD neurological changes (hippocampus, PFC, insular lobe and amygdala) have been investigated structurally and functionally to assess how these abnormalities affect the workings of the brain. The hippocampus is a crucial structure in the development, effects and continuation of PTSD. The results have shown a statistically significant reduction in volume…
In Inside Out, Riley’s memories are stored as orbs, stored in a limitless library, organized into different categories. This library is a simpliar way of referring the hippocampus. The movie doesn’t touch much on this, but each memory is sorted and put into alike divisions so they are easy to recall. Each memory has an emotion tied to it, which the movie emphaizes. Riley has Joy, Fear, Disgust, Anger, or Sadness connected…
Phineas Gage Investigators have considered the cerebrum for a significant long time to find the exact part of the brain in scholarly limits. Phineas P Gage, a railroad improvement expert got a traumatic personality change, which gives learning into accurately how a Traumatic Brain Damage (TBI) affects scholarly limits. Phineas Gage's incident uncovered basic information about how the brain settings support mental limit when a (TBI) happens. A couple structures shape the cerebrum, which accept a…
in the development of certain lobes of the brain compared to other participants of the same sex and age that were of a higher socioeconomic status. There were also structural differences between low and high SES participants in areas such as the hippocampus and the frontal and temporal lobes, which are all associated…
Halle Pietro 11/11/16 Memory Essay Psy101-092WB The mind is a very mysterious process that researchers and doctors still do not completely understand. It is a giant complex command center that is capable of knowing everything because of all that it is exposed to. In memory video 1, they discuss “The Mind Hidden and Divided”. The video is an overview of Sigmund Freud’s research and how certain events and experiences originating in the subconscious understanding of our conscious lives. The topics…
"Implicit memory is shown when performing on a task is enabled in the absence of conscious remembrance; explicit memory is unmasked when the performance on a task requires conscious memory of previous occurrences (Graf and Schacter, 1985 in Anderson, 2015) and conveyed in typical tests of cued and free recall and recognition. Event memory loss after an injury is called anterograde amnesia which involves the extended hippocampal complex and the thalamus which helps form new memories (Salnaitis,…
multitasking. When a task is isolated, learned on its own, the part of the brain that is used to learn the task is the hippocampus. This shows promise because the hippocampus has the authority to oversee declarative memory, and use what was learned in new situations. On the other hand, if a task is learned while multitasking, it is all accomplished using the striatum rather than the hippocampus. Memory learned by the striatum is less adaptable to different situations and therefore your brain…
connected to the cerebral cortex, hippocampus, and spinal cord to receive sensory information. The sensory…