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    Telomeres

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    Introduction The field of telomere biology has been an active area of research in recent time, especially so following the work by Hayflick and Olovnikov. Expanding on his, Elizabeth Blackburn and Joseph Gall noticed that the end of the chromosomes from Tetrahymena thermophila contained the six base sequence TTGGGG iterated many times (Blackburn and Gall, 1978). Over the decades, literature has arisen that has revealed many things regarding telomeres. However, as with the case with many scientific endeavours, as one question is answered, another would arise. As a result, research in telomere biology has become one which many are deciding to take on. We know that proper replication of the telomeric DNA at chromosome ends is critical for…

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    Dyskeratosis Congenita

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    Dyskeratosis congenita (DKC) is a rare congenital disorder that results from defects in telomere maintenance due to mutations in genes coding for proteins that participate in telomere maintenance. It is a progressive disease with a highly variable phenotype, making diagnosis difficult. The disease is characterized by the classic triad of abnormal skin pigmentation, nail dystrophy, and oral leukoplakia (white patches in the mouth) (Figure 1) but these symptoms might not always manifest in…

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    Systemic Telomere

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    Systemic Telomere Length and Aging Telomeres represent essential structure for genome stability, since their role is to protect the extremities of linear chromosomes from degradation and recombination. Furthermore, they also participate in the nuclear architecture, as well as in the meiosis-specific genome recombination and reorganization. Telomere length is the result of the equilibrium between shortening and lengthening mechanisms, and in many different organisms there is a decrease in…

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    Chronological lifespan of S. cerevisiae mutants lacking telomere capping protein Cdc13 and Exo1 Lay summary For over 25 years, yeast has been used as a model to understand cellular processes such as how; DNA is repaired and produced, also for understanding different aspects of the cell lifecycle and principle molecular processes in eukaryotes (the same type of cells that make up humans, animals and plants). Because yeast can be easily grown until it dies in a relatively short time, it is an…

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    function of our life and all life is to reproduce but to get to that we have over came many challenges. On Chromosome 14, the presence of the TEP1 gene seems to be the source of the long lived existence of life on earth. TEP1 codes for a protein that part of telomerase, which is inherently important for the immortality of cells in the human body. At the end of every chromosome, there is a section of repetitive nucleotides sequence called telomeres. The TEP1…

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    their discovery of telomeres and telomerases; but what are they and why did the Nobel prize committee find their discovery so important? Drs ezilabeth Blackburn, Jack Szostak and Carol Greiders discovery of telomeres and telomerases can be considered as one of the key milestones in our understanding of DNA replication in eukaryotes as they helped us figure out how the ends of linear chromosomes are replicated. There discovery of telomeres and telomerase did not only fil A DNA molecule is…

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    S. Crevisiae Essay

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    silencing at HM loci, telomeres and other regions of the chromosome have been shown to relate to stress resistance and aging in Saccharomyces cerevisiae. S. cerevisiae is a species of yeast in which goes through asymmetrical cellular division. Its lifespan is measured by the number of cellular divisions the mother cell is able to complete before death. In the research study by Kennedy et al, the researchers focused on yeast cells and how stress tolerance can extend lifespan through silencing…

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    Highlands Ranch, CO, June 22, 2012 Dr. Chad Prusmack, through his nutraceutical company PruTectRx, has been authorized by T.A. Sciences to prescribe the telomerase activator, TA-65. Popularized by Suzanne Somers in her book, Bombshell: Explosive Medical Secrets that Will Redefine Aging, TA-65 has been shown to lengthen telomeres in DNA strands, which can help slow aging, hinder the development of cancer and decrease genomic instability. TA-65 is only available through authorized,…

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    Soda is an addiction and all addictions have corruptive side-effects. Some side-effects of soda include irritability, restlessness, tension, insomnia, high blood pressure, gastrointestinal disturbance, excessive urination, irregular heartbeat, cell damage, dehydration, an impaired digestive system, liver problems, metabolic syndrome, accelerated aging, and cancer. Soda has toxic chemicals-brominated vegetable oil, or BVO, is an example. BVO is an industrial chemical used as a flame retardant in…

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    Essay On Senescence

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    Classically, senescence is broadly categorized into two types 1) Replicative senescence and 2) Stress induced premature senescence (SIPS). Replicative senescence is induced in cells due to shortening of telomeres as a result of prolonged cell proliferation (discussed later), while premature senescence is induced in cells in response to cell intrinsic as well as extrinsic stresses such as oncogene activation, UV irradiation, DNA damaging agents, inadequate cell culture conditions, reactive…

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