Telomerase

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  • The Importance Of The 2009 Nobel Prize For Physiology And DNA

    The 2009 Nobel prize for Physiology and Medicine was awarded to Drs Elizabeth Blackburn, Jack Szostak and Carol Greider for their discovery of telomeres and telomerases; but what are they and why did the Nobel prize committee find their discovery so important? Drs ezilabeth Blackburn, Jack Szostak and Carol Greiders discovery of telomeres and telomerases can be considered as one of the key milestones in our understanding of DNA replication in eukaryotes as they helped us figure out how the ends of linear chromosomes are replicated. There discovery of telomeres and telomerase did not only fil A DNA molecule is made up of two strands of polynucleotides which can be described as anti-parallel meaning one strand is moving from a 3’ to 5’ direction…

    Words: 1758 - Pages: 8
  • Effects Of Senescence

    Senescence is a robust tumor suppressive mechanism that inhibits the proliferation of damaged as well as initiated cells in response to a diverse range of stresses. The observations that human benign cancer precursor lesions are comprised of senescent cells further provide evidence that senescence is a physiological mechanism that prevents cancer progression in humans, possibly at an early stage. Senescence is clearly not fail-safe, since cells in pre-cursor lesions occasionally progress towards…

    Words: 969 - Pages: 4
  • Informative Essay On Carol Grieder

    professor. Her family moved from San Diego to Davis California. Carol is dyslexic and states that her compensatory skills also played a role in her success as a scientist because one has to intuit many different things that are going on the same time and imply those to a particular problem. Body Paragraph 2: This paragraph will describe what the major discoveries they made including what they discovered about cells. Carol W. Grieder had been the first one to discover a scientific enzyme which…

    Words: 567 - Pages: 3
  • Analysis Of Immortality By Matt Ridley

    TEP1 gene seems to be the source of the long lived existence of life on earth. TEP1 codes for a protein that part of telomerase, which is inherently important for the immortality of cells in the human body. At the end of every chromosome, there is a section of repetitive nucleotides sequence called telomeres. The TEP1 gene codes for telomerase, an enzymes that increases the length of the telomeres after every division of the a cell. Every time cell division occurs the telomere reduces by several…

    Words: 739 - Pages: 3
  • Importance Of Telomeres

    Telomerase, due to its TERT sub unit, is an enzyme that has a reverse transcriptase function (Autexier and Lue, 2006). The TTAGGG repeat sequences can be added to each telomere structure since it can use a short RNA strand as a template to synthesise telomeric DNA repeat sequences at the end of chromosomes, lengthening the telomeric sequence, this was true in Tetrahymena thermophila (Blackburn, 1991). From Hayflick’s observation in 1965, it is now known that each somatic cell division shortens…

    Words: 1944 - Pages: 8
  • Immortality Is A Myth Essay

    eighties. The lifespan of a person is based on technology and not a magical pill. As time passes, the average lifespan of a person will grow because new discoveries will be made. Immortality though is just a myth. The recent scientific developments in the past years have brought up a few possibilities though. One of the promising ways is to try to use the enzyme telomerase to conquer the limit of somatic cell divisions to help slow down cell senescence (Lucke, and Hall). In 1961, Leonard…

    Words: 1299 - Pages: 6
  • The Chronological Lifespan Of S. Ceerevisiae Mutants

    exonucleases would elicit the same response to a double stranded break, ultimately leading loss of cell viability. This is prevented with the binding of specific telomeric proteins to the ssDNA overhang; this allows the telomere to loop back on itself (forming a T-loop,) the end of the ssDNA displaces the double helix and binds to a DNA strand (forming a D-loop). These proteins are key in numerous pathways that protect and maintain chromatid ends (Ngo and Lydall, 2010; de Lange, 2004). Telomere…

    Words: 2050 - Pages: 9
  • Effects Of Mineral Deficiencies

    are healthy. Additionally, it is important to have oxygen in the body because oxygen is important of brain and muscle function. Magnesium deficiency also has a variety of negative health effects on the body. Some of the symptoms of magnesium deficiency are high levels of anxiety, dizziness, weakness, low blood pressure, headaches, seizures, sleep disorders, and restless leg syndrome. Magnesium deficiency has been shown to be related to multiple diseases. Some of these diseases are…

    Words: 839 - Pages: 4
  • Favism In Biology

    but varies depending on the organism. The limit is related to the loss of telomeres, which are buffers that sit at the end of chromosomes. 35. Telomeres are “genetic buffers” on the ends of chromosomes. Whenever a cell reproduces it loses DNA on the end of the chromosomes, so to prevent this DNA from being lost and causing damage, the telomeres contain extra information to protect the important DNA. So each time the cell reproduces, the telomere is shortened, but when the 52-60 limit is reached,…

    Words: 1960 - Pages: 8
  • Survival Of The Sickest Case Study

    The Hayflick limit works because of the telomeres. As soon as the telomeres run out, a cell is stopped. But with telomerase, cancer cells can add on to telomeres repeatedly, meaning the telomeres don’t run out. Telomeres are replenished so quickly that the Hayflick limit never has the chance to start, the cell’s DNA is protected by an everlasting set of telomeres. Scientists are working to finish a test that will immediately trace any signs of increased telomerase activity. This will lead to…

    Words: 1922 - Pages: 8
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