Telomerase

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    The 2009 Nobel prize for Physiology and Medicine was awarded to Drs Elizabeth Blackburn, Jack Szostak and Carol Greider for their discovery of telomeres and telomerases; but what are they and why did the Nobel prize committee find their discovery so important? Drs ezilabeth Blackburn, Jack Szostak and Carol Greiders discovery of telomeres and telomerases can be considered as one of the key milestones in our understanding of DNA replication in eukaryotes as they helped us figure out how the ends of linear chromosomes are replicated. There discovery of telomeres and telomerase did not only fil A DNA molecule is made up of two strands of polynucleotides which can be described as anti-parallel meaning one strand is moving from a 3’ to 5’ direction…

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    Dyskeratosis Congenita

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    however(Dokal et al., 2011; Khincha et al., 2014). Hematopoietic stem cell transplantation can cure or ameliorate some of the blood abnormalities caused by DKC, especially in patients with bone marrow failure. However, this treatment will not affect the tissue damage caused by DKC(Sakaguchi et al., 2013). Additionally, fatal pulmonary complications as a result of this transplantation are common. Patients with DKC have a higher sensitivity towards radiation and chemotherapy drugs so treatment of…

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    Essay On Senescence

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    Senescence is a robust tumor suppressive mechanism that inhibits the proliferation of damaged as well as initiated cells in response to a diverse range of stresses. The observations that human benign cancer precursor lesions are comprised of senescent cells further provide evidence that senescence is a physiological mechanism that prevents cancer progression in humans, possibly at an early stage. Senescence is clearly not fail-safe, since cells in pre-cursor lesions occasionally progress towards…

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    Telomerase Lab Report

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    researching about the possibility of using telomerase inhibitors to kill cancer cells, we first need to know what cancer is and what telomerase is. Cancer is the name used to describe the diseases in which cell have abnormal growth or cell divides is uncontrollable and it will affect other cells. These cancer can spread to other part of the body through the blood or lymph systems. Many people think that cancer is just a disease, in fact, cancer is not just a disease but it consists of hundred…

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    Telomerase Research Paper

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    Telomerase enzyme is apart of the Cancer cell hallmark 4, which is the unlimited cell division hallmark. “Activation of telomerase enzyme, an oncogene which allows cells to divide indefinitely” (2). Typically a cell will stop dividing on it’s own and when the cell divides without telomerase happening, the telomeres will be shorten down. Telomeres is the the ends of the chromosomes. “During development of a multi-cellular a special enzyme called telomerase keeps your telomeres long” (2). When it…

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    is to reproduce but to get to that we have over came many challenges. On Chromosome 14, the presence of the TEP1 gene seems to be the source of the long lived existence of life on earth. TEP1 codes for a protein that part of telomerase, which is inherently important for the immortality of cells in the human body. At the end of every chromosome, there is a section of repetitive nucleotides sequence called telomeres. The TEP1…

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    professor. Her family moved from San Diego to Davis California. Carol is dyslexic and states that her compensatory skills also played a role in her success as a scientist because one has to intuit many different things that are going on the same time and imply those to a particular problem. Body Paragraph 2: This paragraph will describe what the major discoveries they made including what they discovered about cells. Carol W. Grieder had been the first one to discover a scientific enzyme which…

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    A Modest Proposal

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    Telomerase is an enzyme which catalyzes the addition of telomeres to the ends of chromosomes. Telomeres are repetitive non-coding segments found at the end of chromosomes with the sequence TTAGGG. Telomeres act as protective caps for the chromosomes, similar to plastic caps on the ends of shoelaces. Because DNA polymerase can only synthesize in the 5’ to 3’ direction and only adds nucleotides to an existing 3’ end, DNA polymerase is unable to replicate DNA near the 3’ end of chromosomes. This…

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    Carol W.Greider is a biologist who discovered something very important. When she completed her Ph.D. from the university of Cal Berkeley She then went of into researching of the cell. She then saw a thing called a telomerase that can cause cancer if destroyed. She was researching in Long Island, New York when she discovered a protein that stops telomerase from disintegrating. She then got the nobel peace prize for discovering that in the year 2009. Carol Greider was born in San Diego she then…

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    Greider discovered how chromosomes are protected by telomeres and enzyme telomerase. Telomerase is the ends of the chromosome. She and one other scientist determined that it was the enzyme that was responsible for telomerase addition. Telomerase is also the key enzyme in cancer and anemia research. Her discovery of these things are very important in cell…

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