Crystallography

1) A. In 1947 Francis Crick began working with Max Perutz at the Cavendish Laboratory in Cambridge. He began working on a new sector of the Laboratory where X-ray crystallography was being used in order to study protein structure. Crick's thesis project at the university was on X-ray diffraction of proteins. Crick then met John Watson and together they solved the structure of DNA using available X-ray data at the time and model building. After discovering the double helix model, Crick and…

Dorothy Hodgkin, also known as Dorothy Crowfoot Hodgkin and born as Dorothy Mary Hodgkin was a British Biochemist. She was born on May 12, 1910, and died July 29, 1994. (84 years old) Dorothy was born on May 12, 1910, in Cairo, Egypt to her father, John Winter Crowfoot and her mother Grace Mary Crowfoot. Her parents were both archaeologists which were safe to assume inspired her to what she became. Of the four children that Dorothy’s parents had, Dorothy was the oldest of the bunch. While…

The story of Rosalind Franklin not only emphasizes the important role od women in the field of science, it also discusses the challenges and obstacles that woman of science faced and continue to face. Although Watson and Crick worked to study the structure of DNA, they would not have been able to complete their research without the Photo 51; a photo stolen from Rosalind Franklin. Although Franklin was so integral to the discovery of the structure of DNA and her work was stolen from her, she was…

James Watson, Francis Crick, Rosalind Franklin and Maurice Wilkins all played a pivotal role in determining the structure of the DNA molecule. The orderly and methodical work at King’s college, London by Rosalind Franklin and Maurice Wilkins provided a more experimental approach, working closely with X-ray diffraction images of DNA, this was juxtaposed to Watson and Cricks who at their Cambridge lab approached research by building physical models, narrowing down possibilities and producing ever…

and received a scholarship in math. In 1912, Lawrence took his first class honors in Science. That year, he was very interested in learning about the diffraction of X-Rays by crystals. Lawrence Bragg and his father started researching X-Ray crystallography. While continuing his studies, Lawrence served as technical adviser on sound of the British army in France from 1915 to 1919. Afterwards, from 1919 to 1937, Bragg was a professor of Physics at Victoria of Manchester. In 1921, he married Alice…

creation, and another pair of scientists were looking to find how its structure worked. Rosalind Franklin and Maurice Wilkins(bottom photos) worked on tried to piece together the structure of DNA through pictures that were taken through x-ray crystallography, using the fractured light to make sense of the whole thing. Watson and Crick on the other hand went for the Linus…

Process and analyse information from secondary sources to explain a modern example of ‘natural’ selection. (Structural, Physiological, Behaviour) Some organisms, such as bacteria and insects, produce large numbers of offspring. Amongst large numbers of bacteria offspring, some individuals may carry genes that give them resistance to antibiotics. These individuals are then able to survive and reproduce with reduced competition from other members of the same species. Each generation will produce a…

Crick’s lectures, and left a positive review (Olby, Francis Crick: Hunter of Life’s Secrets, 295). After Watson and Crick initially met, they eventually decided to work together. With their combined experience “they decided not to focus on x-ray crystallography”, but instead chose to build models of the molecule (Moitra 20). The model building focus left them with a need for the facts. In order to build an accurate model, Watson and Crick needed research to base the model off of. After speaking…

catalysis theory proposed by Kim and Wyckoff (16). As mentioned, Ser102 acts as a nucleophile and facilitates the departure of an alcohol group during the first step of this reaction. In order for this occur, Ser102 has to be deprotonated. X-ray crystallography has been used to examine the mechanism of alkaline phosphatase. In this study, two new x-ray structures of AP in the presence and absence of inorganic phosphate were obtained and refined to 1.75 Å (9,16). By analyzing these new findings,…

The book I read for my Biology book report was, The Double Helix, A Personal Account of the Discovery of the Structure of DNA an autobiography written by James D. Watson. It was released in 1968 and was published by Atheneum Press (US), Weidenfeld & Nicolson (UK) and is 226 pages. As the title suggests, the book is Dr. Watson’s personal account of the groundbreaking discovery of the structure of DNA. Biologists already knew that genes were the material responsible for traits getting passed from…