Cannabinoids

As of now, two cannabinoids (marijuana), dronabinol (Marinol) and nabilone (Cesamet), are approved by the US Food and Drug Administration for use in chemotherapy induced nausea and vomiting (CINV).1 According to an article about the use of cannabinoids and the treatment of chemotherapy side effects, cannabinoids are shown to have a significant neuro-modulatory function in decreasing CINV.1 CB1 cannabinoid receptors are present in the central nervous system, while recent evidence proposes that CB2 receptors are present on brainstem neurons. Both CB1 and CB2 receptors may have a role in mediating the cannabinoid effects on vomiting. Whether through a CB1 receptor agonist or with CB2 binding, cannabinoids directly and indirectly affect serotonin,…

CANNABINOIDS – TERPENES Cannabinoids CBG-A Formula: C22H32O4 Molecular Mass: 360.48708 g/mol LD50 (Lethal Dose): Unknown. May be similar to CBG, 300mg/kg for mice. (Compare to Nicotine for rats – 50mg/kg) Therapeutic Uses: Analgesic Antibacterial Anti-inflammatory Anti-proliferative (inhibits cancer cell growth) Cannabigerollic acid (CBGa) makes all other medicinal effects of cannabis possible. Through different types of biosynthesis it becomes THCa/THC, CBDa/CBD, CBCa/CBC and CBG. CBGa…

Scientist from around the world closely study and review cannabis and its effects on the body including clinical trials. Studies of marijuana have uncovered over 60 different, biologically active cannabinoids. Many of these different cannabinoids hold different therapeutic properties. These include neuroprotective, anti-cancer, anti-bacterial, and anti-diabetic properties. In science today there are over 22,000 published studies and reviews of cannabis and cannabinoids. Marijuana has been in…

“Studies in the early 1970s showed that marijuana, when smoked, lowered intraocular pressure (IOP) in people with normal pressure and those with glaucoma.” With these positive effects on glaucoma it can slow the progression of the disease and prevent blindness. Epilepsy is one of the most common neurological conditions. About one percent of the American population has epilepsy and about 30 percent is resistant to the anticonvulsant drug treatments. Marijuana can be used to help treat epilepsy…

Two cannabinoids are approved by the FDA for the treatment of chemotherapy related nausea and vomiting in patients who have not responded to the standard therapy given("Cannabis and Cannabinoids"). Cannabinoid receptors found in brain cells have a role in controlling nausea and vomiting. Animal studies have shown that THC and other cannabinoids act on cannabinoid receptors to prevent vomiting caused by certain types of chemotherapy ("Cannabis and Cannabinoids"). When patients can not control…

THC works by mimicking the effects of pre-existing neurotransmitters in our brain known as cannabinoids. Cannabinoids are present in all mammals, fish and reptiles. They work by altering the activity of neurotransmitters within the brain which as a result cause the brain to function at a steady rate. THC causes specific regions of the brain that deal with thoughts, imagination, and perception to heighten to a point where whatever your senses pick up and/or you are thinking about will become…

laws. Spice, also referred to as K2, is a common street name for synthetic marijuana. Classified as a synthetic cannabinoid, spice is composed of materials such as, leaves and lawn clippings (Garber-Paul, 2006). Naturally, the question might arise as to how a piece of grass that you can pluck from your front lawn, attempts to mimic the effects of cannabinoids such as, THC found within marijuana. The answer to that is through the use of industrial chemicals (Garber-Paul, 2006). This is what makes…

It also suggested that consolidation and retrieval were likely unaffected by marijuana use. The early onset group did show learning weaknesses that did not show up in the late onset group or the control group. This suggests that early onset users are vulnerable due to the adolescent brain development being interrupted by exogenous cannabinoids. The results showed differences in clustering strategies among the early onset users, which did not match the researchers’ postulation about serial…

of crime epidemics, this is far from true. In Colorado, for example, where recreational use of cannabis is legal, they have seen a 15% decrease in crime and a staggering 50% in murder. Marijuana consumption does not cause users to become violent and disorderly, but instead actually makes users calmer and more relaxed, as opposed to alcohol. Alcohol poisoning and abuse isn't an uncommon occurrence and can be lethal after consuming too much. It is also thought that cannabis overdose is possible…

Cannabis, or cannabis sativa, originated in Central Asia and has been used for its psychoactive properties for many years (Iversen, 2008, p. 6). It affects the brain of adolescents and adults differently through the binding of CB1 receptors due to distinctions in neurocognitive development. There are certain changes in gray and white matter densities, brain volume, as well as endocannabinoid concentrations. This creates aberrations in cognition and memory performance. Cannabinoid’s structures…