Next, a new class of natural antimicrobial agent, teixobactin is recently found as a strong bactericidal agent which is active against MRSA treatment. Teixobactin is produced by Eleftheria terrae, a new species of β-proteobacteria which belongs to a new a new genus related to Aquabacteria. Teixobactin is a depsipeptide which contains compounds such as enduracidin, methylphenylalanine and four D-amino acids that involves in inhibiting the synthesis of peptidoglycan. According to Ling et al’s…
Coagulation Inhibitors Protein C plays crucial role in controlling anticoagulation and is a vitamin K-dependent serine protease (zymogen). Protein S (a vitamin K- dependent glycoprotein) acts as a cofactor for APC (activated protein C) [133]. Protein C and S slow the coagulation cascade with inactivating coagulation factors such as factor Va and VIIIa. Protein C and protein S are division of a feedback control mechanism, in which excess thrombin production causes protein C…
How glucose levels are re-established when a disruption in the system by internal influences are made. An example of an internal influence that disrupts the negative feedback system of blood glucose regulation is diabetes. Diabetes is a disease in which the body is not able to absorb enough glucose into cells or does not get converted into glycogen, either because of the lack of insulin in the body or because the body does not respond to the insulin properly. Because the negative feedback…
Project Summary Hypothesis Statement: The Atypical Protein Kinase C Zeta (PKMz) is the molecular mechanism underlying Long Term Potentiation (LTP) maintenance at the synaptic membrane. Furthermore, this process is regulated at the level of translation of a locally available pool of PKMz mRNA, and can be sustained in part by active PKMz itself, or inhibited via an activity-dependent translation block. Significance: If the effects of a true PKMz conditional knockout result in memory impairments…
The protein that was found in the first DNA sequence is Apolipoprotein E. The name Apolipoprotein is referred to APOE (APOE). Apolipoprotein E is inside the body and combines with fats to form lipoproteins (APOE). Lipoproteins travel through the blood stream caring cholesterol and other fats (APOE). The fats, cholesterol, and other minerals in the body need to be regulated to prevent a disease occurring from Apolipoprotein E. The protein Apolipoprotein E can cause Alzheimer’s disease.…
After transcribing and translating the sequence I found out that the protein from my DNA sequence is Dystrophin. Dystrophin is known as the DMD gene or Duchene Muscular Dystrophy. (“DMD”, 2015)This gene is one of the largest known human genes in the body. Dystrophin is used for movement such as your muscles and your heart. Dystrophin also plays a role in cell signaling. This sends and receives protein chemical signals. (“DMD”, 2015) Dystrophin is not only important for the structure, but the…
Proteins are complex molecules that serve a variety of functions within the body. Proteins are made up of subunits called amino acids. There are several different types of amino acids such as lysine, aspartic acid, and histidine. Each type of amino acids have their own specific group called R-groups attached to them, this causes them to behave chemically different. The group on the amino acid histidine cause the amino acid to be basic; this feature of histidine makes it have a specific purpose…
Finger nails are made up of keratin protein (the same keratin found in hair), which is formed by amino acids, and produced by living skin cells. The main components that make up a nail consists of; the nail plate which is located at the top of the nail. It is held together by protein fibers. The nail plate needs blood flow, oxygenation, and nutrients to grow. This is why an injured nail sometimes turns bruised or falls off. Oxygen penetrates through the nail plate. The nail bed is the skin…
Recent technological advances in biology have prompted me to want to study the subject as an undergraduate. I have been drawn to how the world works and what everything is made up of since secondary school, but in recent months my focus has shifted specifically towards the study of genetics. A wide and varied subject, ranging from eugenics and the ethical considerations of genetically engineering organisms, and to the more recent scientific breakthroughs in said area of study, the study of…
This means finding proteins that express affinity and specificity for the respective ligand. According to Ewald (2011) there are three good options, CitX (periplasmic binding protein from Salmonella typhimurium) and the binding domains of DpiB (sensor histidine kinase from E. coli) and CitA (sensor histidine kinase from Klebsiella pneumoniae). We would then purify all three proteins and record fluorescence energy values when bound to citrate for future…