Unified Parkinson's Disease Rating Scale

Parkinson’s disease is a progressive neurological disorder. People with Parkinson’s have a deficiency in dopamine which results in tremors, rigidity, bradykinesia and autonomic dysfunction. According to the Scottish Intercollegiate Guidelines Network (SIGN) (2010), out of every 100,000 people, between 120 and 230 people are living with Parkinson’s in Scotland. Furthermore Parkinson’s disease can affect people from all age groups and ethnic backgrounds. However the majority of people diagnosed…

The condition of Parkinson’s Disease has been known since ancient times, but known as a different name, “shaky palsy.” In 1817, London doctor James Parkinson published a medical essay on the disease which is where the name, “Parkinson’s” originated (“Parkinson’s Disease History,” para. 1). The publication Parkinson wrote established Parkinson’s Disease as an actual medical condition and encouraged others to study the disease (“Parkinson’s Disease History,” para. 2). With Parkinson’s work, French…

commands are created in a division of the prefrontal cortex (responsible for higher level cognition) known as the neocortex. The neocortex houses the motor cortex and thus is responsible for motor control, which is the primary impairment in Parkinson’s Disease (Kaas & Stepniewska, 2016 SD). Onset typically follows a significant drop in the presence of the neurotransmitter dopamine, which in this case is generated from a part of the brain called the substantia nigra. The substantia nigra supplies…

Parkinson’s Disease In individuals who develop Parkinson’s disease the nerve cells that produce dopamine in the substantia nigra die off. These nerve cells relay message that control body movements. The other parts of the brain that impact movement and become damaged in people with Parkinson’s include: the striatum, basal ganglia, and cerebellum. The striatum collects information, and along with the substantia nigra, which is located in the midbrain, is responsible for sending impulses from the…

Introduction Motor neuron diseases (MND) are a group of pathologies in which motor neurons are selectively affected. Amyotrophic lateral Sclerosis (ALS) is a member of this group, affecting both upper (UMN) and lower motor neurons (LMN) [1]. ALS is a progressive neurodegenerative disease [1], with an estimated incidence in Caucasians of about 1,2-4,0 per 100,000 person-years [2]. ALS incidence increases with age, being more frequent between the 6th and 7th decades and in women more than men…

Parkinson’s disease is a medical condition in which movement of the body is affected by an irregularity of the nervous system. The most common symptom that emerges for victims of this disease is tremors as well as stiffness or slowing of movement. Environmental triggers (such as exposure to toxins), genetic mutations, and the increase of age are all factors that contribute to the development of the disease. Although Parkinson’s disease is incurable, treatment can ease the symptoms. Treatments…

Parkinson’s Disease Parkinson's disease is a disorder in the brain, which affects your nervous system. By affecting your powerhouse which in other words the brain it can cause several side effects. This disease can cause shaking and difficulty with walking, any movement of the body, and even face expressions. Parkinson’s disease affects your whole body muscles because it damages your nerve cells in the brain which produce dopamine. The nervous system is the main source that helps you move and…

14, 2015 Parkinson’s Disease The topic that has been chosen for my research paper is Idiopathic Parkinsonism or Parkinson’s disease (PD). Parkinson’s is a neurodegenerative brain disorder that typically will progress slowly (3). It affects the nervous system of mostly elderly people and there is no cure for it. The major symptoms of PD include slowed movement, muscle stiffness, and tremors. “On average, about 1 to 2 out of 1,000 people have Parkinson’s” (4). The Center of Disease Control…

known that this protein causes Parkinson’s disease or PD. Parkinson’s disease is a disorder of the nervous system which causes one to not be able to control their normal movements. The way this works is that there is a malfunction and death of neurons in the brain , specifically substantia nigra, which is the movement control center in the brain. These dying neurons produce dopamine and as time goes on the amount dispersed decreases, therefore causing Parkinson’s disease. This disorder begins…

Parkinson’s disease (PD) is regarded as the second most common neurodegenerative disease and is a result of the loss of dopaminergic cells in the substantia nigra (Robakis and Fahn, 2015). This deficiency of dopamine produces symptoms such as: tremors, rigidity and bradykinesia in affected patients (de Lau and Breteler, 2006). It is thought that the mitochondrial enzyme, monoamine oxidase (MAO), is involved in the neuropathology of PD. MAO is a flavoenzyme that catalyzes the oxidative…