Onset: Impairment In Parkinson's Disease

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In the human body, motor commands are created in a division of the prefrontal cortex (responsible for higher level cognition) known as the neocortex. The neocortex houses the motor cortex and thus is responsible for motor control, which is the primary impairment in Parkinson’s Disease (Kaas & Stepniewska, 2016 SD). Onset typically follows a significant drop in the presence of the neurotransmitter dopamine, which in this case is generated from a part of the brain called the substantia nigra. The substantia nigra supplies neurotransmitter to the striatum, a region which receives input from the neocortex and contains the neurons, or nerve cells needed for movement (Trafton, 2013 MIT). In a typical neural motor pathway, an initial or pre-synaptic

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