History Parkinson disease was coined by James Parkinson, an English apothecary surgeon, political an activist, paleontologist and geologist in 1817. He described the disease as a shaking palsy that involves resting tremor, diminished muscles strength, paralysis, unusual posture and gait, and how it progresses overtime. Sixty years later, Jean Martin Charcot, a French neurologist and professor of anatomical pathology, also the founder of modern neurology. He clearly defined the disease as a slow progressive…
Parkinson’s disease is the second most common neurodegenerative disorder; it is responsible for the loss of dompaminergic neurons in the substantia nigra (Kakkar, Bae). Nearly five million people are affected worldwide and around one million are affected in the United States alone (Kakkar). The symptoms vary from motor symptoms, bradykinesia, muscular ridgity, resting tremor, and postural impairment, to non-motor, depression and anxiety (Kakkar). Early indicators of the disease are usually psychiatric…
Creutzfeldt-Jakob disease Creutzfeldt-Jakob Disease (CJD)= a universally fatal neurodegenerative disease • Swift: Kills 90% of patients within 1 year of prognosis • Rare: 1 case out of 1 million people worldwide Phenotypes= observable characteristics of an individual with CJD • Cognitive: Disorientation, memory loss, mental confusion, dementia o Ex. “I have trouble falling down” • Muscular: Slow body movement, jerking muscle spasms, coordination impairment o Ex. balance problems • Other: Blurred…