Substantia nigra

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  • Calbindin Essay

    Anti-Calbindin binds to Calbindin (CB) and labels GABAergic neurons In our immunohistochemistry (IHC) experiment, we used anti-Calbindin as our primary antibody, Goat anti-Rabbit 488 IgG as our secondary antibody (“488” meaning that the fluorescent dye is excited at a wavelength of 488nm, fluorescing green), and DAPI-mounting serum as a DNA (nucleus) marker with blue fluorescence for reference against anti-Calbindin-marked GABAergic neurons (Lammel, 2016). While GABAergic-neuron-expressing anti-Calbindin labeled various regions of the brain such as, midbrain reticular nucleus (MRN), Red nucleus (RN), Substantia Nigra pars reticulate (SNr), and Interpeduncular nucleus (IPN), our region of study was focused on the ventral tegmentum area (VTA) and the prefrontal cortex (PFC). Role of Calbindin (CB) Calbindin (CB) has four active calcium-binding sites (with two sites that lost their capacity to bind to calcium), called EF hands…

    Words: 1122 - Pages: 5
  • Hypoxia Case Study Essay

    disease, which according to Dr. Bautista and Dr. Grossman is a progressive movement disorder related to the basal-ganglia of the brain, which control movement of the body. At the end of the substantia nigra of the basal ganglia lies the pathway to muscle cells that use dopamine as the neurotransmitter (Bautista & Grossman, 2014). This nigrostriatal pathway is disrupted in Parkinson’s disease, and 70-80% of the neurons need to be lost before clinical symptoms of Parkinson’s develop (Lehne, 2013).…

    Words: 1818 - Pages: 8
  • James Prkinson's Disease Case Study

    PARKINSON’S DISEASE PD is irreversible, progressive disease, described by James Prkinson’s in 1817 in “An essay on the Shaking Palsy”. The incidence of PD increases with age, more than 2.6% population of age 85-90 are affected, some rare cases individuals with age group 60 above are affected approximately 0.6% (54). Majority are idiopathic. Signs include difficulty in movement, tremor, rigidity. Pathologically, PD affects a part of substantia nigra. Patients those who are suffering from PD are…

    Words: 593 - Pages: 3
  • Parkinson's Disease Case Study

    possibility of a misdiagnosis even though they still commonly occur in the diagnostic process (Parkinson’s UK 2016). Symptoms such as trembling, sleeping disorder, depression, dementia and difficulty swallowing are not unique to Parkinson 's; patients with diseases such as progressive supranuclear palsy express similar symptoms (Parkinson’s UK 2016, Izawa et al. 2011). Recently, the focus of the scientific community has been to discover methods or procedures which can eliminate the chances of…

    Words: 842 - Pages: 4
  • Parkinson Communication Theory

    communication methods and practices, and to further support inclusive practice in order to help the Parkinson’s service users overcome the difficulties and problems that they come across in their daily lives. This information leaflet aims to guide staff members on how to effectively communicate with Parkinson’s service users, understand communication methods and practice, and to further support inclusive practice. But first, we will discuss what is Parkinson’s disease and how it affects the…

    Words: 1149 - Pages: 5
  • The Central Nervous System

    The human body is extremely complex and made up of various systems and organs that must work together. When one part does not function the way it is suppose to, it can slow down the functions of the other parts, which can be detrimental . A quote by Doris Lessing states that when one’s body malfunctions or contains chemical imbalances, “It makes you aware of the knife-edge we live on”. In order for the human body to function correctly, the central nervous system, endocrine, and peripheral…

    Words: 1120 - Pages: 5
  • Parkinson's Disease Causes

    Causes The causes of Parkinson’s Disease remain unknown, however there have been several theories as to what could cause the debilitating disease. Factors such as age, and genetic predisposition play a major role in the development of the disease. The disease is most common in those over sixty, however, it could take over twenty years for symptoms to develop. Age is the most common factor in the development of the disease, however if the disease is detected early, then it is most likely due to…

    Words: 1883 - Pages: 8
  • The Black Walnut Tree Analysis

    "The Black Walnut Tree" is a contention between the strict and non-literal, the down to earth and wistful. In an obvious actuality, verging on contemptuous tone, the mother and daughter discuss cutting downed selling the tree to pay off their home loan. In any case, with a move to more metaphorical dialect comes a change to a more typical perspective of the black walnut tree: it is an image of their family legacy and father's work, and however the home loan measures overwhelming, chopping down…

    Words: 705 - Pages: 3
  • Nervous System Case Study

    brain the body would not work (Craig Freudenrich, 2015). Case Study 2: Glen Early onset Parkinson’s disease is a chronic progressive neurological disease that targets neurons in the substantia nigra (American Parkinson Disease Association, 2015). The substantia nigra produces a neurotransmitter called dopamine. This neurotransmitter aids in the rewards and pleasures centers of the brain, as well as coordinating and balancing of in the muscles. In addition to targeting the substantia nigra,…

    Words: 1108 - Pages: 4
  • Parkinson Disease History

    shaking palsy that involves resting tremor, diminished muscles strength, paralysis, unusual posture and gait, and how it progresses overtime. Sixty years later, Jean Martin Charcot, a French neurologist and professor of anatomical pathology, also the founder of modern neurology. He clearly defined the disease as a slow progressive disease of the central nervous system that leads to motor impairment. It involves extensive degenerative changes in the basal ganglia which has a role in movement. As…

    Words: 391 - Pages: 2
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