Substitution reactions

6. If t-butyl bromide was used as a substrate instead of t-butyl chloride the reaction rate would stay the same. The mechanism will still be SN1 reaction for the same reasons as t-butyl chloride. Such as, t-butyl bromide is tertiary alkyl halide like t-butyl chloride which will also favors SN1 reaction when reacted with water, a weak nucleophile. It will also form 30 carbocation which are more stable in SN1 reaction mechanisms as having more R groups (CH3 in this experiment) on the carbon with…

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The goal of this lab was to conduct the reaction of 2-methyl-2-butanol with HCl to form 2-chloro-2-methylbutane, and to understand Sn1 and Sn2 reactions, in terms of how they are different and why one is more likely to happen over the other. The OH group in 2-methl-2-butanol is attached to a tertiary Carbon, meaning the reaction should occur via Sn1, a two-step reaction, and Cl should replace the OH group, to form a tertiary halide. HCl was added to 2-methyl-2-butanol and then several…

Nucleophilic substitution Nucleophilic substitution reaction is that in which attacking nucleophile replaces a leaving group. Attacking nucleophile: specie with an electron free pair or negative charge and ability to replace already present nucleophile i.e OH- Leaving group: A specie with electron deficiency or positive charge, negative charge i.e Cl- What is SN1 Reaction:- SN1 indicates the unimolecular nucleophilic substitution reactions. Their rate determining step of the mechanism depends…

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This experiment was performed in order to demonstrate the principles of nitration through electrophilic aromatic substitution. It also examined the effects of bromine on an aromatic ring, ortho-para vs. meso directing. The second experiment was performed to compare the reaction rates of electrophilic aromatic bromination with different arenes. Data and Results In the gas chromatogram, there are two large peaks. The first peak at 0.653 minutes with an area of 133,352 uV per second, 31.95% of…

Magnesium ion is required for generating Ser102 nucleophile Stec et al. suggested a reaction mechanism involving three metal ions, which is modified from the two metal ion catalysis theory proposed by Kim and Wyckoff (16). As mentioned, Ser102 acts as a nucleophile and facilitates the departure of an alcohol group during the first step of this reaction. In order for this occur, Ser102 has to be deprotonated. X-ray crystallography has been used to examine the mechanism of alkaline phosphatase.…

2-Bromoheptane + Potassium TertButoxide reaction yielded 3 different products: 1-heptene, Cis-2-heptene and Trans-2-heptene. However, the major product constituent was 1-heptene. Because Potassium TertButoxide is a bulky base, steric hindrance prevents it from attacking a hydrogen on a highly substituted carbon. Consequently, the base attacks a hydrogen on the least substituted carbon (primary carbon). In this case, steric hindrance is reduced and the elimination reaction is faster, so a less…

Thus only NB atom can be protonated. Gabriel Amine Synthesis (Preparation of 1o amines) The Gabriel Amine synthesis is a three-step organic reaction that converts an alkyl halide to a primary amine. The advantage offered by Gabriel Amine synthesis is that it avoids poly-alkylation. Step 1: acid-base reaction. The acidic phthalimide molecule gets deprotonated by a strong base. The strength of an acid depends on the stability of the conjugate base. The negative charge on…

Nucleophilic Acyl Substitution: The Synthesis of Esters Razon, Valjean Paulo Mella Rico, Fatima Sarah Rogel Institute of Chemistry, University of the Philippines, Diliman, Quezon City 1101 Philippines…