Osteosarcoma

The two critical needs in treatment to treat osteosarcoma is to prevent relapse into osteosarcoma and better treatments after surgery. Current treatments in osteosarcoma involve surgery, chemotherapy and radiation therapy. However, the chances of cancer relapses are extremely high. Thus, we need more efficient post-surgery treatments to prevent relapsing of a much stronger cancer. Several new drugs for chemotherapy are being tested to provide better results but none of the drug alone has shown any promising results. However, Sorafenib and everolimus have been tested to use as a treatment if the chemotherapy is given after surgery had failed to prevent relapses of osteosarcoma. Even though this treatment has not reached the 50% Progression Free…

Even though there is a multitude of ways to treat osteosarcoma, the most conventional ways to treat it are through combinations of surgery, chemotherapy, and radiation therapy. It has been found that giving a patient chemotherapy before and after surgery is one of the most effective ways to cure osteosarcoma (1). However, in certain cases radiation therapy may be necessary. For nearly all cases of osteosarcoma, surgery is necessary. However, surgery alone is seldom successful because often…

Osteosarcoma is a relatively radioresistant Tumor. Thus, adjuvant chemotherapy and surgery have been the backbones of treatment. Prophylactic whole lung irradiation was utilized in the late 1970s as a method for decreasing lung metastases post-operatively (Breur, Cohen, Schweisguth, & Hart, 1978). Prebiopsy Low-dose irradiation (around 10 Gy) can be given before the initial biopsy in order to decrease the viability of the malignant cells that can be disseminated into the circulatory system…

Bone Cancer is a malignant tumor of the bone that destroys normal bone tissue. Benign bone tumors are more common than malignant ones. Benign tumors do not spread, do not destroy bone tissue, and are rarely a threat to life. Amyotrophic Lateral Sclerosis (ALS), or Lou Gehrig’s Disease, was first found in 1869 by French neurologist Jean-Martin Charcot, but it wasn’t until 1939 that Lou Gehrig brought national and international attention to the disease. (ALS) is a progressive neurodegenerative…

Osteosarcoma is an aggressive form of cancer that affects the bone growth locations in the body known as epiphyseal plate. Cancer occurs when the body’s cells being to divide at an astounding rate, but in the case of Osteogenic Sarcoma the cells are multiplying rapidly and creating a weak bone matrix replacing the healthy bone matrix. This disease affects young adults because bone growth is quicker in their bodies. It especially targets bones like the femur, tibia, humerus, but is not limited to…

When we hear the word cancer, our hearts automatically sink into our stomachs. Now, imagine you are just a child and your parents are told you have Osteosarcoma. This is a type of cancer that is most commonly found in those between the ages of 10 to 20 years old, and often found in the long bones of the body; thigh, shin, or humerus (“Types of Childhood Cancer” 2015). Keep in mind that the cancer can vary with each child. Osteosarcoma can be detected by a child being in severe pain and the…

Osteosarcoma (osteogenic sarcoma) is very rare bone cancer that begins in the cells that form bones. It most often occurs in the long bones that are in arms and legs. The bones that are infected are immature and have a weaker bone matrix than normal bones, and tumors grow on the infected area. There are 800 new U.S. cases per year, 400 of which are diagnosed in teenagers. The main symptoms of osteosarcoma include bone pain in a certain area, swelling, bone tissue formation, and limping.…

Osteosarcoma is a type of cancer that starts in the bones. Osteosarcoma develops in children as well as young adults in areas where bone grows quickly. Types of osteosarcoma can be determined by what shows up on an imaging test. The cancer can be classified as High-grade, Intermediate-grade, and Low-grade. High-grade osteosarcomas are the fastest growing osteosarcoma. When studied under a microscope, many cells dividing into new cells are observed. High-grade most often is seen in children. Some…

Osteosarcoma (OS) is the most common primary tumor of bone and the third most common malignancy in adolescents. OSs of all sites accounts for approximately 40-60% of all malignant tumors of bone. Approximately 6-13% are tumors that form in the craniofacial skeleton (1-4) . Appendicular OS, another type of bone tumor has a higher success rate than craniofacial OS, as over 75% of these patients are likely to survive in the longer run. The higher rate is apparent despite Appendicular OS not having…

Osteosarcoma is the most frequent malignant tumor of the bone in the pediatric age group, with an incidence of 8.7 per million in children and adolescent under the age of 20 years (Meyers and Gorlick, 1997). Its incidence peaks during the second decade of life, coinciding with the adolescent growth spurt. It is more commonly seen in the metaphyseal region of long bones; the distal femur, proximal tibia and proximal humerus being the most common sites and they correspond to areas of active growth…