Osteosarcoma is a relatively radioresistant Tumor. Thus, adjuvant chemotherapy and surgery have been the backbones of treatment. Prophylactic whole lung irradiation was utilized in the late 1970s as a method for decreasing lung metastases post-operatively (Breur, Cohen, Schweisguth, & Hart, 1978).
Prebiopsy Low-dose irradiation (around 10 Gy) can be given before the initial biopsy in order to decrease the viability of the malignant cells that can be disseminated into the circulatory system by the biopsy. However, a previous study found no distinctions in survival rate between patients receiving radiotherapy before biopsy and historic controls, which discouraged additional investigation (Halperin, Constine, Tarbell, & Kun, 2004).
Local disease In current …show more content…
A previous study reported that seven patients with osteosarcoma of the spine who received postoperative irradiation had a higher long-term survival (∼50%) than those who did not (∼10%) (Ozaki et al., 2002).
Extracorporeal irradiation Among the more innovative uses of radiation in osteosarcoma treatment has been extracorporeal irradiation. Bone is taken out for irradiation and then reimplanted into the body. Reimplantation of irradiated bone provides several theoretical advantages contrasted to limb- saving methods. A major advantage is the exact anatomic fit of the reimplanted bone fragment. It avoids the growth discrepancy commonly seen in prosthetic substitutions, the graft rejection, and the danger of viral transmission. It is also theoretically possible that dead tumor cells in the irradiated bone may stimulate a desirable immunologic reaction (Yamamoto, Akisue, Marui, Nagira, & Kurosaka, 2002).There was no evidence of local recurrence or symptoms of graft failure such as extreme pain or severe fracture happening in patients treated with extracorporeal irradiation (50 Gy) (Araki et al., 1999).
Lung
Prebiopsy Low-dose irradiation (around 10 Gy) can be given before the initial biopsy in order to decrease the viability of the malignant cells that can be disseminated into the circulatory system by the biopsy. However, a previous study found no distinctions in survival rate between patients receiving radiotherapy before biopsy and historic controls, which discouraged additional investigation (Halperin, Constine, Tarbell, & Kun, 2004).
Local disease In current …show more content…
A previous study reported that seven patients with osteosarcoma of the spine who received postoperative irradiation had a higher long-term survival (∼50%) than those who did not (∼10%) (Ozaki et al., 2002).
Extracorporeal irradiation Among the more innovative uses of radiation in osteosarcoma treatment has been extracorporeal irradiation. Bone is taken out for irradiation and then reimplanted into the body. Reimplantation of irradiated bone provides several theoretical advantages contrasted to limb- saving methods. A major advantage is the exact anatomic fit of the reimplanted bone fragment. It avoids the growth discrepancy commonly seen in prosthetic substitutions, the graft rejection, and the danger of viral transmission. It is also theoretically possible that dead tumor cells in the irradiated bone may stimulate a desirable immunologic reaction (Yamamoto, Akisue, Marui, Nagira, & Kurosaka, 2002).There was no evidence of local recurrence or symptoms of graft failure such as extreme pain or severe fracture happening in patients treated with extracorporeal irradiation (50 Gy) (Araki et al., 1999).
Lung