It is impossible to rule out mural invasion with one incisional biopsy of the lining of a unicystic ameloblastoma because of the potential for taking a non-representative tissue sample. In unsuspected cases where a biopsy is not taken and unicystic ameloblastoma with mural invasion detected after primary conservative treatment, there is a dilemma whether the patient should receive further treatment to eliminate possible residual ameloblastoma tissue in the surrounding cancellous bone as suggested by some1,8, or be regularly observed with radiographs for possible recurrence but without necessarily any additional intervention unless and until a recurrence is detected. Raising the index of suspicion and undertaking a biopsy of every radiolucent
