Metformin

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  • Metformin Synthesis

    view Metformin improves the insulin resistance primarily in muscle, liver, and adipose tissues by reducing the liver glucose output, largely due to a diminution in the rate of glycogenolysis and gluconeogenesis (97). Various beneficial effects of metformin include attenuation of abnormal glucose metabolism, weight loss, improvement of insulin resistance, endothelial dysfunction, subclinical inflammation, lipid-lowering properties, antineoplastic potential and cardiovascular protection. Metformin itself is a non-nephrotoxic drug which was initially chosen as the safest hypoglycemic substance in chronic renal failure. However, its use has been limited in these patients because of the perceived risk of lactic acidosis (98).…

    Words: 1182 - Pages: 5
  • Polycystic Ovary Syndrome

    Polycystic ovary syndrome (PCOS) is a problematic, life changing disorder for many females. According to the National Institute of Health (NIH) (2014) in the United States alone, PCOS affects roughly 5 million female of reproductive age. The price tag to identify and manage PCOS is about 4 billion dollars yearly (NIH, 2014). Background Information PCOS is a complicated disorder that involves the endocrine system. Research has shown that it is a condition that is often present in women of…

    Words: 910 - Pages: 4
  • Gastroretentive System Of Metformin: Approaches To Effervescent Tablets

    Gastroretentive System of Metformin: Approaches to Effervescent Tablet Sudhanshu K Chakravati1, Javed Khan Pathan1, Sapna Malviya1, Anil Kharia1 Modern Institute of Pharmaceutical Sciences, Indore (MP) ABSTRACT Effervescent tablet generally contains in addition to active ingredients, mixture of acids/acid salts (Citric, Tartaric, Malic acid or any other suitable acid or acid anhydride) and carbonate and hydrogen carbonates (Sodium, Potassium or any other suitable alkali metal carbonate or…

    Words: 3536 - Pages: 15
  • Dr. Reddy's Laboratories Case Study

    algorithm, the first line of treatment for Type-II diabetes is Metformin. Metformin belong to a class of drug called Biguanide. The discovery of this drug can be traced back to the pioneering work with extracts of the herb Galega officinalis, which led to the characterization of the blood lowering effects of an active ingredient named galegine. Market Summary: Though Metformin has been used successfully since the 1950s as first line pharmacotherapy to treat people with type 2 diabetes, the…

    Words: 1306 - Pages: 6
  • Type 2 Diabetes: Case Study

    The first trial conducted by Grunberger et al included 167 patients with type 2 diabetes for 3.9 years with A1c of 7.2 ± 0.6% who were on metformin or had failed metformin.3 The patients were either taking a placebo, dulaglutide 0.1 mg, dulaglutide 0.5 mg, dulaglutide 1 mg, dulaglutide 1.5 mg. The results showed that patients in each of the dulaglutide treatments had significant (p-value <0.001) A1c reduction, with 75% of the patients in each treatment reaching A1c <7% and 50% reaching A1c…

    Words: 1143 - Pages: 5
  • Case Study On Diabetes

    This was a Phase III, Multi-center, randomized, bioequivalence (BE) study of the fixed dose combination (FDC) of saxagliptin/metformin extended release (XR) relative to co-administration of the individual drugs components in 2 cohorts of healthy male subjects under fed conditions.. The 2 cohorts were independent of each other with respect to treatment and results. Clinical Study Report Synopsis Drug Substance Saxagliptin/Metformin Study Code XXXXXXXXXXXXX. Healthy males aged ≥18 years and ≤50…

    Words: 918 - Pages: 4
  • P261-264 Physical Activity

    for difficult situations. F. Goal setting. G. Stimulus control. H. Self-monitoring. IV.5. PHARMACOTHERAPY: The rationale for pharmacotherapy (153, 154, 155): Pharmacologic agents provide modest to moderate, short-term reduction in body weight cardiovascular risk factors and are unlikely to be clinically useful in adolescents with severe obesity. Their effects appear to be facilitated by lifestyle change. Their efficacy appears highly variable among individuals, which may reflect genetic…

    Words: 1683 - Pages: 7
  • Why Do Caregivers Value Their Culture

    often suffer nerve damage and complications that lead to dangerous infections and the need for amputation. Type-2 diabetes leads to adult blindness in many (citation). Increased blood glucose levels lead to complications and damage to vessels, veins and arteries throughout the body. Type-2 diabetes is frequently treated with oral medications such as metformin. Medicine however, is not the only treatment for diabetes. Mild cases of type-2 diabetes can be controlled, and at times even reversed,…

    Words: 706 - Pages: 3
  • Nateglinide

    antidiabetic medications can be separated by mechanism of action into two groups: hypoglycemics (sulfonylureas and meglitinides) and antihyperglycemics (biguanides and alpha-glucosidase inhibitors). The hypoglycemic agents pose a significant risk of morbidity, mortality, and permanent sequelae secondary to prolonged periods of hypoglycemia. However, outcomes are routinely good if intervention is initiated early, with the primary goal return of euglycemia using supplemental dextrose infusion and…

    Words: 1627 - Pages: 7
  • STEMI Case Study

    Mr. D 's EKG results show that his STEMI was effecting the inferior right coronary artery and the lateral circumflex artery. While Mr. D was in the emergency department he was order oxygen at 2 L/min via nasal cannulae, aspirin 325mg chewable orally, nitroglycerin 0.4mg sublingual one every five minutes up to three times (hold if systolic blood pressure is s HbA1c level is indicative of type 2 diabetes and is prescribed metformin to control his glucose levels. Metformin decreases the liver…

    Words: 1155 - Pages: 5
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