Metformin

In the UK, drug therapy of T2DM shifted from sulphonylureas to metformin (Hamada and Gulliford, 2015). In this case, metformin prescription has largely increased from 55.4% in 2000 to 83.6% in 2013 and sulfonylureas decreased from 64.8% to 41.4% in 2000 and 2013 respectively. In relation to insulin, prescription remained stable with 20-24% of treated patients (Sharma, Nazareth and Petersen, 2016). In other countries, metformin is reported to be the most commonly prescribed drug for patients with drug monotherapy (Mor et al., 2015; Higgins et al., 2016). In relation to newly diagnosed patients, from 2003 to 2005 a retrospective study in the UK reported that 36%, 42% and 51% of patients with T2DM initiated with antihyperglycemic therapy within…

Polycystic ovary syndrome (PCOS) is a problematic, life changing disorder for many females. According to the National Institute of Health (NIH) (2014) in the United States alone, PCOS affects roughly 5 million female of reproductive age. The price tag to identify and manage PCOS is about 4 billion dollars yearly (NIH, 2014). Background Information PCOS is a complicated disorder that involves the endocrine system. Research has shown that it is a condition that is often present in women of…

Sitagliptin is a drug that has proven its effectiveness towards managing type 2 diabetes. Type 2 diabetes is a progressive disease characterized by relative lack of insulin. It consists of insulin resistance as well as dysfunction of β-cells. Insulin resistance indicates that more insulin is required for normal body functioning along with decreased insulin concentration at all levels.4 This lowers the glucose transporter action associated with insulin deficiency.4 Malfunctioning of pancreatic…

Conclusion In review of the broad spectrum of studies, it proves that metformin is a better drug choice for treating pregnant women who have GDM. The use of metformin promotes glycemic control (Ibrahim, M, 2014). These studies produced marginal biases, and the methods used to conduct the research were suitable. The data gathered from each study indicated that metformin is similar to insulin in glycemic control. By using metformin, the body reduces the amount of glucose production, it also…

view Metformin improves the insulin resistance primarily in muscle, liver, and adipose tissues by reducing the liver glucose output, largely due to a diminution in the rate of glycogenolysis and gluconeogenesis (97). Various beneficial effects of metformin include attenuation of abnormal glucose metabolism, weight loss, improvement of insulin resistance, endothelial dysfunction, subclinical inflammation, lipid-lowering properties, antineoplastic potential and cardiovascular protection. Metformin…

intervention. The medical care provider may give medicines or natural remedies for Metformin diarrhea control. Another contributing factor is a higher dosage. If the starting dose is high or increased too quickly, this can cause diarrhea. The drug is available in the following forms: • Oral immediate release tablet • Oral extended release tablet • Oral solution Patients on oral immediate release tablet are at a greater risk of experiencing Metformin with diarrhea after eating when…

Knowler et al., (2002) and Gilles et al., (2007) metformin has shown to reduce the risk from progression of prediabetes to diabetes. Moin et al., (2002) case-control study looking at causality examined metformin prescription use for diabetes prevention in individuals with identified prediabetes over a three year period in 17,352 working-age adults. Of the total sample size on 3.7% of patients with prediabetes were actually prescribed metformin. Women, obese, or those with two or more comorbid…

Pharmaceuticals such as antihyperglycemic medications may also be an option to keep blood sugar levels on track. Oral antidiabetic agent metformin and glyburide have shown efficacy with no evidence of harm to the foetus, although long-term safety remains a concern (28.) When comparing to two, metformin was a 2.1 times higher failure rate than glyburide. Metformin works by decreasing the amount of glucose the liver makes, keeping blood sugar levels low and boosting insulin response. Although…

Gastroretentive System of Metformin: Approaches to Effervescent Tablet Sudhanshu K Chakravati1, Javed Khan Pathan1, Sapna Malviya1, Anil Kharia1 Modern Institute of Pharmaceutical Sciences, Indore (MP) ABSTRACT Effervescent tablet generally contains in addition to active ingredients, mixture of acids/acid salts (Citric, Tartaric, Malic acid or any other suitable acid or acid anhydride) and carbonate and hydrogen carbonates (Sodium, Potassium or any other suitable alkali metal carbonate or…

the extremes of starving themselves. Excess weight can affect one’s self-esteem. Metformin 500 mg and weight loss are closely related. Research has proved that Metformin 500 mg weight loss tablet can help you shed off the extra pound. It’s unclear how the Metformin HCL ER works for one to lose weight, one theory claims one of the side effects of Metformin 500 mg is the loss of appetite causing you to eat less thus weight loss. One rule of losing weight is to lose more calories and consume…