Gastroretentive System Of Metformin: Approaches To Effervescent Tablets

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Gastroretentive System of Metformin: Approaches to Effervescent Tablet

Sudhanshu K Chakravati1, Javed Khan Pathan1, Sapna Malviya1, Anil Kharia1
Modern Institute of Pharmaceutical Sciences, Indore (MP)

ABSTRACT Effervescent tablet generally contains in addition to active ingredients, mixture of acids/acid salts (Citric, Tartaric, Malic acid or any other suitable acid or acid anhydride) and carbonate and hydrogen carbonates (Sodium, Potassium or any other suitable alkali metal carbonate or hydrogen carbonate) which release carbon dioxide when mixed with water. Occasionally, active ingredient itself could act as the acid or alkali metal compound necessary for effervescent reaction. Effervescent tablets are uncoated tablets that generally contain acid substances and carbonates or bicarbonates and which react rapidly in the presence of water by releasing carbon dioxide. Effervescent tablets are designed to produce a
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(mg) F-3
(mg)
Metformin Hydrochloride 250 250 250
Citric Acid _ 180 360
Tartaric Acid 360 180 _
Sodium Carbonate _ 90 180
Pottasium Carbonate 180 90 _
Manitol _ 45 90
Polyvinyl Pyrolidone 90 45 _
Talc 35 35 35
Magnesium State 35 35 35
Saccharine 10 10 10
Total Weight 960 960 960

Method of Effervesent Tablets of
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All the ingredients were accurately weighed and passed through sieves No 44# and in order to mixed the ingredients properly. Drug and different concentration of Sodium bicarbonate, Citric acid, Talc and Magnesium stearate, Pottasium carbonate, Manitol, sorbitol, Sweetner (Saccharine) Polymer were blend in mortar followed by the addition of Polyvinyl pyrolidone (PVP), After thoroughly mixing the ingredients tablets were compressed in rotary punching (using 10 mm flat punch) machine. Three formulations were prepared and coded them from F-1 to F-3 and evaluated for Pre-Compression parameters, Post-Compression [1, 22, 24, 25,

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