picture on its own is not enough. A picture with a description is acceptable. (5 points) When cystic fibrosis transmembrane conductance regulator CTFR channels are functioning normally, they allow chloride ions to move outside of the cell. When the CTFR is mutated the chloride ions are unable to leave out of the cell channel which causes a thick coat of mucus lining the outside of the cell. Cystic Fibrosis is caused by mutations in the CTFR gene. The CTFR gene is composed of 1480 amino acids and…
In cystic fibrosis the CFTR gene does not produce the chloride pump protein, so water cannot move into the mucus making it very thick and sticky. This abnormally thick mucus builds up in passageways causing obstructions and harboring bacteria that cause infections, especially in the lungs and the pancreas. In the lungs this thick mucus leads to difficulty breathing and because of the bacteria that gets trapped and stuck in the mucus that lines the lungs people with cystic fibrosis suffer from…
In Cystic Fibrosis, symptoms start slowly. The respiratory tract (nose to lungs) and the gastrointestinal (digestive) systems are the most affected. Symptoms usually start in the gastrointestinal system. Male fertility and sweat glands are also affected. Only about fifteen percent of babies who carry the disease have meconium ileus which is sticky and thick caused by thick mucus from intestinal glands. Vomiting and abdominal swelling are caused and surgery right after birth is needed usually. If…
Juvenile rheumatoid arthritis (JRA) is an inflammation of the joints that is the result of the body’s own immune system attacking the joints (Peacock & Ostrov, 2000). Juvenile rheumatoid arthritis is also known as juvenile idiopathic arthritis (JIA) (Brescia, 2012). There are seven major types of JRA, which are: systemic JIA; oligoarthritis; polyarticular arthritis, rheumatoid factor negative; polyarticular arthritis, rheumatoid factor positive; psoriatic arthritis; enthesitis-related…
Cystic fibrosis (CF), is a disease that is inherited, or passed down through genes from parents to offspring. This disease affects the secretory glands, including the glands that produce mucus and sweat. People with CF have inherited two faulty CF genes, one from each parent. Parents, likely don 't have the disease. CF affects many body organs but mostly the lungs, pancreas, liver, intestines, sinuses, and sex organs (What Is Cystic Fibrosis?, 2013). CF is gentically transmitted as an autosomal…
When there are genetic mutations that affect the cystic fibrosis trans-membrane conductance regulator (CFTR) protein, Cystic Fibrosis (CF) is the outcome. CF was recently linked to CFTR defects, which is a major gene, found on the seventh chromosome. Cystic Fibrosis is not only the most common disease among those of Caucasian decent, but it also happens to be the most deadly inherited disease that affects more often Caucasian Americans. In the United States one in twenty among Caucasians are…
During the 1930’s and 40’s, the majority of children diagnosed with Cystic Fibrosis died in the first couple years of their lives. ("Prognosis") This unfortunate reality is caused by the effect of the inherited disease, Cystic Fibrosis; this sickness is caused by the build-up of excess mucus that has the potential to permanently damage one’s lungs. Cystic Fibrosis, also known as CF, Cystic Fibrosis of Pancreas, Fibrocystic Disease of Pancreas, or Mucoviscidosis, is a non-contagious genetic…
Contrary to what one would expect based on the title of her book, The Forever Fix: Gene Therapy and the Boy Who Saved It, Ricki Lewis pens a narrative science focused on the milestones in the history of gene therapy, not just one success story (Lewis, 2012). Corey Haas, the boy who regained his vision after being sentenced to a life of blindness, is only one of the medical miracles mentioned; the book also devotes itself to presenting the theory and procedures behind gene therapy. As a…
Introduction Up to this point in our respiratory care education we have learned a great deal about therapies and drugs that eliminate, mediate, or prevent symptoms of common respiratory conditions like COPD, asthma, cystic fibrosis, tuberculosis, etc. Most of our focus has been centered around improving patient’s gas exchange by relaxing airway smooth muscle, clearing secretions, expanding airways, and decreasing inflammation. As we have eluded to in many scenarios leading up to this point,…
were able to view many different things including very small organisms. The invention of the external pacemaker saved many lives back in 1950, one of the inventors needed his own invention to save his life for some time. The discovery of the Cystic Fibrosis also helped with the progression in medical technology because doctors were able to learn so much more about the disease and how it works. When Sir Wilfrid Laurier predicted that “Canada shall be the star towards which all men who love…