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  • Prometheus Anser Ifx Testing Case Study

    A review of the records reveals the member to be young male with a birth date of 01/15/1999. The member has a diagnosis of Crohn’s disease. His provider, Reinaldo Garcia-Naveiro, M.D. recommended Prometheus Anser IFX diagnostic testing that was performed on 12/15/14. The carrier has denied coverage of Prometheus Anser IFX testing as investigational. There is a letter to Nancy Twigg from the carrier dated 11/24/15. In the letter, the carrier states in part: “The submitted medical records were reviewed. In accordance with the Medical Mutual Corporate Medical Policy 201303 for Genetic Testing and Genetic Counseling General Policy, it was determined that the Prometheus Anser IFX is investigational. This test has insufficient evidence for improved outcomes.” Discussion: The member is a 17 year old with a history of Crohn’s disease with active symptoms of non-bloody diarrhea, with 4 loose stools/day, fatigue and growth failure without abdominal pain or peripheral manifestations of IBD (Irritable Bowel Disease). He has been managed on Remicade, methotrexate, iron and folic acid. A colonoscopy found active inflammation at the IC valve and concern of possible secondary failure led to Prometheus Anser IFX trough level testing on 11/04/2014. The levels returned ruling out anti drug antibodies and found IFX in detectable levels By way of background, the Prometheus® Anser™ IFX assay is a proprietary test that measures both serum infliximab levels and antibodies to infliximab,…

    Words: 1214 - Pages: 5
  • Systemic Lupus Research Paper

    Etanercept is taken for varying forms of arthritis. It is a TNF blocker, and works by blocking protein (TNF-alpha) that causes inflammation. However, its side effects include the weakening of the immune system, which can cause autoimmune diseases. Adalimumab treats various inflammatory conditions including, Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, etc. If you are taking a TNF blocker (like Etanercept) you can develop cancers like…

    Words: 1142 - Pages: 5
  • Aspects Of Hydroxychloroquine

    Results Of 11,996 articles, 15 articles were reviewed for this systematic review that were relevant to clinical research topic. The results from the articles were used to address the question which treatment immunosuppressives or corticosteroids is better in treating adolescents with systemic lupus erythematosus. Immunosuppressives reviewed in this paper are Hydroxychloroquine, Methotrexate, Cyclophosphamide, Rituximab, Azathioprine, Mycophenolate Mofetil, Anti-cytokines (including anti-TNF…

    Words: 1655 - Pages: 7
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