Mononegavirales

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  • Ebola Disease Essay

    Ebola virus disease EVD or “Ebola” is a severe human and non-human primate disease caused by Ebola viruses. These viruses belongs to the family: Filoviridae, Genus: Ebolavirus, Species: Tai forest ebolavirus (TAFV), Reston ebolavirus (RESTV), Sudan ebolavirus (SUDV), Zaire ebolavirus (EBOV) and Bundibugy ebolavirus (BOBV) (Bukreyev et al., 2014). Zaire ebolavirus or simply Ebola virus (EBOV) is the most virulent of the genus and accounts for the highest numbers of outbreaks. The virus spreads by direct contact with body fluids or secretions of infected animals. Although the natural reservoir of the virus is yet to be ascertained, fruit Bats has experimentally been “implicated” as the natural host (Swanepoel et al., 1996). Humans get infected through direct physical contact with infected bat or other animals (duikers and non-human primates) that serve as intermediate host. Ebola virus then spreads among humans through contact with symptomatic person or infected fomite. There have been various speculations with regards to the pathogenesis of EBOV. Generally, studies have shown that on a successful entry into body tissues, the virus invade the immune system suppressing the production and response of interferon proteins using its VP24 and VP35 (Hoenen, Groseth, Falzarano, & Feldmann, 2006). It infect monocytes, macrophages and dendritic cells resulting in rapid viral replication, hemorrhage and hypovolemic shock and edema, fever and gastrointestinal dysfunction (Lai, Ng, & Cheng,…

    Words: 976 - Pages: 4
  • Ebola In The Hot Zone

    The Hot Zone by Richard Preston is a non-fiction novel about the origin of Ebola and its effects on people and the outbreak of Ebola in a monkey house. Preston also goes into details about the symptoms of Ebola and the different strains of Ebola,which are Ebola Zaire, Ebola Reston, and Ebola Sudan. Preston really informs about the dangers of Ebola and what it can do to the human body and what must be done to prevent the virus from spreading around the world and causing an…

    Words: 854 - Pages: 4
  • Ebola Disease

    INTRODUCTION The Ebola virus disease (EVD) was first identified in 1976 during two simultaneous outbreaks, one in Sudan and the other in Democratic Republic of Congo. Since then there have been 24 outbreaks involving 28,635 reported cases and 11,314 deaths according to the World Health Organization (REFERENCE). EVD is an example of an “emerging/ re-emerging” pathogen, due to its divergent genomes and sporadic outbreaks causing severe hemorrhaging fever in humans and non-human primates. The…

    Words: 742 - Pages: 3
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