Grignard reaction

to prepare the Grignard reagent from aryl or alkyl halides and demonstrate the principles of organometallic chemistry. The Grignard reagent was prepared via a radical mechanism. The Grignard reagent was then used to prepare a carboxylic acid from carbon dioxide, demonstrating its ability to create carbon-carbon bonds by acting as a strong nucleophile. As the R group of the Grignard reagent was unknown, molecular weight and melting point were then used to identify the resulting carboxylic acid. The molecular weight was determined using titration techniques and the melting point was measured using a Mel-Temp Apparatus. Data and Results In the formation of the Grignard reaction, the solution turned cloudy…

This lab was a two week long lab called the Grignard Reaction lab. The purpose of this lab was to perform the Grignard reaction and to obtain the final product triphenylmethanol from a halide, phenylmagnesium bromide and the starting material, methyl benzoate along with the Grignard reagent. Bromobenzene, magnesium turnings, and anhydrous ether were needed to form the Grignard reagent. To synthesize the reagent, react the reagent with methyl benzoate to form a tertiary alcohol. The objective of…

To demonstrate their effectiveness in creating new carbon to carbon bonds, the Grignard arylation of 2-butanone was carried out. The Grignard reaction of phenyl bromide and magnesium, followed by the addition of 2- butanone yielded a crude product of 2-phenyl-2-butanol. The 1H NMR spectra was taken before distillation, showing the crude product, as well as after distillation, showing one of greater purity. In addition, an IR spectrum was taken after distillation. Both the 1H NMR and IR spectra…

Abstract: The Grignard reaction was successfully accomplished. An amount of 1.20 ml of 2-methyl-2-pentanol was collected, and 9.60% yield was calculated based on the theoretical yield. Despite the low amount of 2-methyl-2-pentanol, its identity was confirmed by comparing the experimental refractive index and infrared spectrum to the literature refractive index and infrared spectrum of 2-methyl-2-pentanol. Statement and purpose The purpose of this experiment is to synthesize a specific alcohol…

unsatisfactory, even though the results sustain a general trend throughout the course of the experiment, the results were not expected. At the beginning of the experiment all reagents produced satisfactory results, the reactant 2-bromopropane was determined to be the limiting reagent for the Grignard formation and the Isopropyl Magnesium Bromide was correctly formed. However, random errors occurred at the nucleophilic addition step. At this period, it was observed there was not condensation…

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A possible chemical reason that this experiment yielded less than 100% triphenylcarbinol was caused by the Grignard reagent reacting with atmospheric water or oxygen instead of reacting with benzophenone due to the highly reactive nature of the Grignard reagent and a constant presence of humidity and moisture inside the laboratory. Although extra precautions were taken to dry to glassware and a CaCl2 drying tube was used, there was an unavoidable exposure of the Grignard reagent to atmospheric…

who were out on convoys or patrolling. I remember the day clearly when my Sargent died. There had been a patrol out doing a routine sweep of our area and he stepped on an IED, which basically turned him into pink mist. There was no body to recover. I remember standing at the left corner security post when the blast went off. The blast was large enough to kill him and open cause minor injuries to the other men around him. There was this sense of panic since there was nothing I could do but watch…

There are several different reactions that can be utilized in order to end with a product that includes the synthesis of carbon-carbon bonds, however for this experiment the reaction that was utilized is aldol condensation. An aldol condensation is when an enolizable aldehyde or ketone undergoes a reaction, in the presence of a base or acid, and gives a beta unsaturated ketone or aldehyde (Utah Valley University, 2009). This type of reaction can also add carbonyls to a compound, using similar…

method has been introduced as outlined in the key steps and diagrams (figure 1.3) below. Reduction of the N-Cbz oxazolidinone derived from alanine (Steps 2 to 3) Grignard addition to the lactol to give the amino alcohol (Steps 3 to 4) Chemoselective N-methylation(addition of a methyl (CH3)group ) (Steps 4 to 8) (Figure 1.2 – Steps of synthesis when creating PSE from N-Cbz-L-alanine) In table 1.3, below, the above process is discussed in greater detail step by step as well as specifying the…