Clopidogrel

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    Clopidogrel Resistance

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    Clopidogrel resistance is associated with great adverse outcomes, early recognition of these patients is very important. However the major problem in this issue is the lack of standardized method and cut-off values in definition of clopidogrel resistance. A few methods have been used but none have been fully standardized or fully agreed upon to measure clopidogrel responsiveness [52]. As discussed above platelet function tests are expensive ,time consuming and complicated , however this relatively simple and readily available test; measurement of MPV by automated cell counter, has been accepted as a surrogate marker of platelet function [10]. In the few existing literature about correlation of MPV levels and clopidogrel resistance, Asher et…

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    Overview: The combination of many issues such as prescriptions cost, patients’ economic status, and lack of health insurance, interfere with the patients’ access to their medications. This creates an environmental problem that puts patients at a higher risk for morbidity and mortality, and consequently, increasing the healthcare cost of treatments on health complications due to non-medication compliance (Duke, Raube, & Lipton, 2005, p. 726). Approximately 50 million people in the United States…

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    Clopidogrel Lab Report

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    I. INTRODUCTION: Clopidogrel is one of the major drugs used in the treatment of Acute Coronary Syndrome. Along with Aspirin it is the standard of care in Percutaneous Coronary Interventions with stenting, when a long term dual antiplatelet treatment is needed. However the response to clopidogrel shows wide inter-individual variations. Various studies have shown that the polymorphisms in the genes responsible for Clopidogrel absorption and metabolism are a major factor for these variations.…

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    Bristol Meyers Squibb is a pharmaceutical company, with a very rich tradition. This analysis will begin with a few historical highlights. Edward Squibb was a doctor in the Navy, who was unimpressed by the medicine that the Navy was using during the Mexican War, he was so dissatisfied that he threw all of the unfit medicine overboard. On 1858, when he returned, he went on to start his own company in Brooklyn, New York, with the goal of having pure medicine for the people. Squibb’s medicine was…

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    Cea Case Studies

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    Include antiplatelet and statin in managing patients with carotid artery stenosis and stroke. For patients with stroke secondary to 50% - 99% occlusion of a major intracranial artery, aspirin 325 mg/d is preferred to warfarin. Clopidogrel + Aspirin 325 x 90 days may be used in patients with recent stroke or within the last 30 days caused by 70% - 90% stenosis of a major intracranial artery. Do not…

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    Systematic Review

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    Critique of Systematic Reviews Two systematic review articles will be critiqued and compared in this paper. Article A is titled systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials authored by Kenneth McQuaid and Loren Laine. Article B is titled platelet function testing in transient ischemic attack and ischemic stroke: a comprehensive systematic review of the literature by Soon Lim, Catherine Coughlan, Stephen Murphy, Israel…

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    interactions). Proton pump inhibitors causes few adverse effects with its usage such as upper abdominal pain, dry mouth, constipation, vomiting. dizziness, headache and flatulence but evidence is mounting that these medications can also lead to some troublesome and even serious adverse drug reactions such as bone fractures, hypomagnesmia, community acquired pneumoniae, vitamin B12 malabsorption,clostridium difficile associated diarrhoea. In 124 patients with coronary artery disease (CAD)…

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    Nicotine Research Paper

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    “Clopidogrel is a drug used to inhibit blood clots for those patients suffering from coronary artery disease and other circulatory diseases leading to strokes and heart attacks” (Christopher Wanjek, 2011). Smoking seems to help this drug do its job better by working as a synergist. “A study by Korean researchers in the October 2010 issue of the journal Thrombosis Research stated that something in cigarette smoke activates certain proteins called cytochromes. It converts clopidogrel into a more…

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    NSTEMI in 2013 and 2014, respectively. Mrs. B will be treated based on these guidelines. Immediately on arrival, she will receive the following treatments: supplemental oxygen therapy to keep oxygen saturation greater than 90% or relieve respiratory distress, sublingual nitroglycerin to relieve ischemic pain, and chewable 325mg aspirin for its antiplatelet effect. Morphine sulfate will be considered if chest pain is not relieved by sublingual nitroglycerin or if anxiety or pulmonary edema is…

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    The medications he takes are Metoprolol, Valsartan, Amiodarone, Atorvastatin, Clopidogrel, Metformin and Rivaroxaban. He takes the same three medications for three years now and the same four medications since his bypass surgery. Today, he chooses to have a lively life with an excellent diet and exercise habits. Medication Evaluation My participant, JR had heart bypass surgery, exactly 4 bypasses, on June 1, 2015, due to 90% of his coronary arteries being blocked. This eight-hour surgery was a…

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