The innate immune response is triggers by molecules such as pathogen- associated molecular patterns (PAMPS’s) and damage-associated molecular patterns (DAMPS’s). In comparison to PAMP’s, DAMP’s are only expressed when there has been damage or death to a cell, however they are both recognised by the same receptor, pattern recognition receptor (PRR). Once recognised the receptor then sets about destroying the pathogens or the dead tissue to remove it from the body with the primary response being inflammation. It often damages the host, which is more common when stimuli is present that is persistent and excessive. This process tends to happen is atherosclerosis due to the risk factors and can cause excessive stimulation in the walls of arteries
