Allele frequency

be successful in identifying novel causative mutations of rare or common Mendelian diseases like CVDs and can detect cardiomyopathy-causing mutations with high accuracy [71] because NGS is able to detect the rare genetic variants with a minor allele frequency (MAF) of < 5%, [72]. So, application of NGS tools in the inherited CVDs will be important to define the genetic component of these…

Report begins: The point of existence for a species is to survive and reproduce. The human race is a thriving species with a population that is forever increasing. One of the biggest problems for the human race is curing or preventing diseases that reduce the quality of life and even kill the individuals affected by it. An example of a disease is Adenosine Deaminase deficiency (ADA) which is a very rare disease that creates a poor immunity in the individual affected due the the lack of the…

chromosome, region 1, band 5, sub-band 4 Gene/locus HBB – haemoglobin subunit beta HTML reference Stumpf, A.M. (2013). Sickle cell disease Available form: http://www.omim.org/entry/603903?search=Sickle%20Cell%20Disease&highlight=cell%20sickle%20disease Frequency More than 230 000 children with sickle cell disease are born in Africa every year, which makes about 80% of the global total. In Europe estimated number of affected births is 1300. In England estimated number of people with sickle cell…

2. Discuss the 3 primary causes of human variation. Which do you think has the greatest effect on human variation The Three primary causes of human Variation are Evolutionary Processes, the environment and culture. Evolutionary processes are influenced mainly by genetic diversity that varies between populations. The environment involves life experiences and how it differs amongst individuals, Culture emphasises on variations in belief systems and practise Genetic variation helps us…

An Overview of the Determinant of the Genomic Diversity Genetic diversity provides variation in which that selection can act upon and it determines the response of population towards environmental change. Therefore, knowledge in genetic diversity is crucial for developing breeding strategies and also for the management of endangered species. Understanding the determinant genetic diversity is also essential for resolving the long-standing riddle in population genetics, the disproportionately…

Without treatment some people affected by this disorder would die. Individuals who get treatment are able to reproduce because they have a higher chance of survival. This increases the gene frequency of Polycythemia within the population. This could affect the human population because more people have the gene. However, one could argue that treatment would not increase a person’s fitness because Polycythemia is diagnosed at an older age when…

lab, the purpose was to demonstrate how the Drosophila melanogaster is used in the field of genetics to study the inheritance of traits throughout the F1 and F2 generations. Drosophila melanogaster was introduced into the wild type and other mutant alleles such as white eyed, vestigial, and sepia. The results gathered in the lab would then be compared to actual results, and a Chi-Square test will be used for…

Introduction Alleles are different forms of genes that governor a single genetic trait (Tortora & Derrickson, 2009, p. 1118). Genes, a section of a DNA molecule, are heritable traits that are produced by the DNA of an individual (Tortora & Derrickson, 2009, p. 53). Individuals in a population can be born with multiple different genes or characteristics (Freeman et al., 2014, p. 5). The characteristics that change throughout a population over time are known as evolution (Freeman et al., 2014, p.…

How do scientists explain and support the argument for biological evolution? From the recent trip to the Minnesota Zoo, labs performed in class and multiple readings these things have shown students the dynamics of evolution. Scientists, like Charles Darwin, who have focused studies on certain organisms like the Galapagos Island finches have played a large role in our knowledge today about biological evolution, natural selection and descent with modification. Over many generations and an…

specialists evolving in homogeneous environments. Further reading suggests that the genetics of the niche width is a lot more complex than once thought, especially when considering adaptations and constraints on generalist’s evolution. Negative frequency-dependent selection allows the diversity to be maintained for genetic variation in fitness between heterogeneous and homogeneous environments; heterogeneous’ variation is readily maintained. The conclusion drawn is that environmental…