1. Problem to be addressed.
To study the effect of a paraprobiotic, heat inactivated Lactobacillus gasserei, on the functioning of the central nervous system using mouse models.
2. Background to the problem. The microbial composition of the gut in early life is known to influence the development and functioning of the adult brain, including behavioral functions. Many behavioural disorders like anxiety, depression and autism have been linked to severe damage to the gut microbiota.
Studies have shown that the gut microbiota enhance the synthesis of neurotransmitters by cells lining the gut, fortify the blood-brain barrier by producing short-chain fatty acids and regulate the immune system.
The widespread use of antibiotics, processed foods, agricultural chemicals and chlorinated or fluorinated water has been harmful to the gut flora of humans. Fermented foods and probiotics, which contain live microbes, are being used to remedy this problem. …show more content…
They have the following advantages over probiotics-
Live bacteria, including probiotics, can become opportunistic pathogens in cases of persons with a weakened immune system. This risk would be minimized by the use of heat-inactivated paraprobiotics.
Foods containing paraprobiotics have a longer shelf life and do not need to be kept at a low temperature for storage.
Paraprobiotics may have a beneficial effect on the central nervous system by altering the composition and metabolism of the gut microbiota.
(208
To study the effect of a paraprobiotic, heat inactivated Lactobacillus gasserei, on the functioning of the central nervous system using mouse models.
2. Background to the problem. The microbial composition of the gut in early life is known to influence the development and functioning of the adult brain, including behavioral functions. Many behavioural disorders like anxiety, depression and autism have been linked to severe damage to the gut microbiota.
Studies have shown that the gut microbiota enhance the synthesis of neurotransmitters by cells lining the gut, fortify the blood-brain barrier by producing short-chain fatty acids and regulate the immune system.
The widespread use of antibiotics, processed foods, agricultural chemicals and chlorinated or fluorinated water has been harmful to the gut flora of humans. Fermented foods and probiotics, which contain live microbes, are being used to remedy this problem. …show more content…
They have the following advantages over probiotics-
Live bacteria, including probiotics, can become opportunistic pathogens in cases of persons with a weakened immune system. This risk would be minimized by the use of heat-inactivated paraprobiotics.
Foods containing paraprobiotics have a longer shelf life and do not need to be kept at a low temperature for storage.
Paraprobiotics may have a beneficial effect on the central nervous system by altering the composition and metabolism of the gut microbiota.
(208