Hyperforin

obsessive-compulsive disorder (OCD), and seasonal affective disorder (SAD). It has also been used to help treat exhaustion, fibromyalgia, chronic fatigue syndrome (CFS), migraine and other types of headaches, muscle pain, nerve pain, and irritable bowel syndrome (IBS). It has been used as a smoking cessation adjunct and to treat cancer, HIV/AIDS, and hepatitis C. U.S. National Library of Medicine, (2015). St.John’s Wort. Retrieved October 10, 2015, from https://www.nlm.nih.gov/medlineplus/druginfo/natural/329.html What information can you supply in the following areas regarding the product? Pharmacology (are there specific components/chemicals in the supplement that have a particular effect upon the person using the supplement?) Hypericin and hyperforin are believed to be the main active components in St John’s Wort. It is also composed of common plant constituents such as volatile oil, xanthone derivatives, flavonoids, biapigenin, amentoflavone, and flavonoid derivatives, which may have antidepressant effects but have not been researched extensively. Lawvere, S., & Mahoney, M. C. (2006). St John’s Wort: American Family Physician. Retrieved October 10, 2015 from http://www.researchgate.net/profile/Martin_Mahoney2/publication/7426926_St._John's_wort/links/540d8acc0cf2f2b29a386673.pdf Quinones such as hypericin and pseudohypericin have an anti-depressive action, as well as powerful antiviral effects on herpes simplex viruses I and II, Epstein-Barr, Influenza A and B and…

interactions with St. John’s Wort (Hypericum perforatum): a review of the clinical evidence. Europe PubMed Central. 2004;42(3):139–48. 7. Izzo AA, Ernst E. Interactions Between Herbal Medicines and Prescribed Drugs. Drugs. 2001;61(15):2163–75. 8. Dürr D, Stieger B, Kullak-Ublick GA, Rentsch KM, Steinert HC, Meier PG, et al. St John’s Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clinical Pharmacology and Therapeutics. 2000;68(6):598–604. 9. Johne A,…

the benefit of being an antidepressant, and this is the most common reason that people use this supplement. It contains antidepressant chemicals that will decrease symptoms of depression. But it does more than simply treat depression – taking this supplement will level out mood swings, regulate the bodies' hormones, and help with fatigue, irritability, and sleeplessness. By regulating hormones it has a positive effect on the thyroid and can actually make the thyroid produce correct levels of…

muscle pain and headache, and relieve upset stomach. Currently, St. John’s wort remains a popular herbal remedy for mild to moderate depression, menopausal symptoms, skin redness and irritation, minor wounds, mood disorders and sleep disturbances, as well as shows promising results in therapies for cancer, inflammation, and bacterial/viral infections. In Germany, Saint-John 's-wort is considered as a drug and has been approved/regulated by Commission E (the German equivalent of the USA Food…

antagonist and monoamine oxidase (MAO) inhibitors. Monoamine uptake inhibitors inhibit the uptake of 5-HT and/or noradrenaline by monoaminergic nerve terminals. At the very least antidepressants seems to require 2 weeks to yield any results regardless if the drug need time to act or not. This suggests that there are important adaptive secondary changes. Some evidence indicates that there might be an increase neurogenesis in for example hippocampus when using antidepressants. MONOAMINE UPTAKE…

also induced growth inhibition in HCT116 and Daudi cells [67]. Pyrimidine-based inhibitors [69,70], dibenzo[b,f]azepine-based inhibitors [71] and oxazalo[4,5]pyridine-based inhibitors [72] are among the many new series of sirtuin inhibitors based on unique scaffold. Recently, our group have also identified benzimidazole as a novel scaffold for sirtuin inhibition [73,74]. These compounds inhibit both SIRT1 and SIRT2 in micromolar range and possessed anti proliferative activities against colon,…