Case Study Of Hypericum Perforatum Case

3137 Words 13 Pages
Case study on:

Drug interaction between St. John Wort (Hypericum Perforatum) extract and Ibuprofen as a possible cause of upper gastrointestinal bleeding.


Fabrizio Codebo’

Free Lance Remote Healthcare Provider HCPC Registered Paramedic PA34987

65 Federation Road

Email address (preferred contact):

Correspondence address:
A. Codebo’
Via Della Costa 20 E
Alpignano (To)

Box 1
Description of the Event
The case refers to a 51 year old Caucasian male employed as a technician aboard a vessel experiencing a sudden onset of four, consecutive episodes of haematemesis. The patient expectorated a total of approximately 80 millilitres of frank blood, within the first 20
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Izzo AA. Drug interactions with St. John’s Wort (Hypericum perforatum): a review of the clinical evidence. Europe PubMed Central. 2004;42(3):139–48.
7. Izzo AA, Ernst E. Interactions Between Herbal Medicines and Prescribed Drugs. Drugs. 2001;61(15):2163–75.
8. Dürr D, Stieger B, Kullak-Ublick GA, Rentsch KM, Steinert HC, Meier PG, et al. St John’s Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clinical Pharmacology and Therapeutics. 2000;68(6):598–604.
9. Johne A, Brockmöller J, Bauer S, Maurer A, Langheinrich M, Roots I. Pharmacokinetic interaction of digoxin with an herbal extract from St John’s wort (Hypericum perforatum). Clinical Pharmacology and Therapeutics. 1999;66(4):338–45.
10. Müller WE, Singer A, Wonneman M. Hyperforin--antidepressant activity by a novel mechanism of action. Thieme E-Journals – Pharmacopsychiatry. 2001;34(Suppl 1):98–102.
11. Fugh-Berman A, Ernst E. Herb–drug interactions: review and assessment of report reliability. British Journal of Clinical Pharmacology. 2001;52(5):587–95.
12. Bell EC, Ravis WR, Braxton Lloys K, Stokes TJ. Effects of St. John’s Wort Supplementation on Ibuprofen Pharmacokinetics. The Annals of Pharmacotherapy.

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