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50 Cards in this Set

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epithelial cells have 3 domains

apical


lateral


basal



Apical domain of epithelial tissue is in direct contact with __ or __

lumen or external enviro

apical is specialized for 3 things

secreation


absorp


surface transport

microvilli on apical increaes surface area for

absorp and secreation

microvili also known as

brush border

microvili made of

actin core

microvilli are anchored to

actin cytoskeleton (terminal web)


keeps micrvilli properly oriented

cilium of apical domain are used for __. they are __.

motility


they are projections of plasma membrane and cytoplasm

cilia made of _ in what arrangement

microtubulues in 9 doublets + 2 singlets

cilium help to move _ along _

mucous along surface

4 types of intercellular jncns

tight


adherens


desmosomes


gap jncns

intercell jncns are:


-sites of __ btwn cells


-found in __ cells


-formed by __

sites of adhesion


found in epithelial


formed by CAMs

Tight jncns:


-found at __


-makes a __ btwn cells


-CAMs adhere __ together


-the more stiches, the __

-apical


-restrictive seal


-adhere the plasma membranes together


-more stiches means better seal

tight jncns limits ____.


which is __

paracellular flow!


flow of molecs through gap btwn cells (along lateral)

bc of tight jncns, epithelial cells "__" what crosses epithelial barrier.


__ molecs, which is __ pathway

selects what crosses


endocytoses molecs, which is TRANSCELLULAR pathway

so tight jncns allow epithelia to be

selectively permeable

Adherens jncn:


-doesnt let cells __


-CAMs are linked to __ (makes ___ e density)


-found __

-no let cells separate


-CAMs linked to actin cytoskeleton (fuzzy e density)


-found below tight jncns

Desmosomes:


-doesnt let cells _


-CAMs linked to __ via __ (are like spot welds)


-found __


-look like __

-separate


-interm filaments via disc plaques


-found below adherens jncns


-look like oreos

Gap jncns:


-are for __


-pairs of cell __ molecs form __


-a gap jncn is a cluster of __


-found __

-molecular signalling, nutrients


-adhesion molecs form transmembrane channel


-gap jncn is cluster of these channels


-found almost anywhere along lateral domain

these all make jcnal complex, which is found

only at the apical part of lateral domain AKA TERMINAL BAR

Epithelium had two part classification:


1) Number of cells layers (__ or __)


2) Shape of cells in apical layer (_, _, or _)

simple or stratified


squamous cuboidal or columnar

in Simple, all cells __

contact the basal lamina


ONE LAYER

In stratified, there are __

many layers of cells

in squamous, apical layer is

flattened


nuclei are flat

squamous: good for ___


Present in :

absorbing and diffusing molecs.


found in lungs and blood vessels for absorbing.



in cuboidal, apical layer is _.


is used for

cubed. nuclei in middle.


used for absorb and secrete, but not great at either.

columnar look like __.


nuclei are __


good for __

columns


nuclei are at basal part


good for absorb like in GI tract

Pseudostratified epithelium:


-have dif types of cells that __


-but, all cells ___ so are actually simple!



appear layered


all cells contact the basement membrane

common pseudostratified cell types:


-_ (w cilia)


-


-_ (secrete mucous)

-columnar cells


-basal cells (are at bottom usually)


-goblet cells (look like goblets)

Stratified epithelium:


-consists of _


-only the __ contacts membrane


-second part of name comes frmo ___

-several true layers


-only basal layer


-comes frmo apical layer

basalmost layer in stratified is the __.


-their job is to __

basal cells


-job is to replenish each cell type of epithelium

Keratinized stratified squamous epithelium:


___ can be keratinized or non keratinized

stratified squamous

Keratinized:


-makes barrier that is __ and __


-keratin layer has __ and non keratin layer underneath has ___

tough and water resistant


no nuclei


has nuclei

Transitional epithelium:


-aka __


-is a type of __


-lines lumen of __

urothelium


stratified epithelium


lumen of bladder, ureters, proximal urethra

Trans epithelium:


-apical cells _ and _ dependign on how much __


-when distended: they _



-change shape and flatten depending on how much the lumen is DISTENDED WITH FLUID.


-when distended, they FLATTEN

Metaplasia:


-causes transformation of __ of __ into another type


-is __


-can be caused by chronic inflamm or irritation (like smoking)

type of mature epithelium into another type


REVERSIBLE

the parenchyma of glands is formed by _

epithelial cells specialized to secrete

secretory compounds are stored in cell in

secretory granules

exocrine secretes __ into a _ or _

apically into a duct or a luminal surface

3 types o exocrine

merocrine


apocrine


holocrine

endocrine secretes

basally into bld vessel in STROMA

can tell its an endocrine gland by:

all the e dense secretory granules on the basal side

secretions from endocrine glands go to

vessels in CT

exocrine glands have a __ and a ___

secretory portion and a conducting portion (duct)

exocrine glands can be classified on structure of _ and _

ducts and secretory protein

ducts classifications

simple and compound (branch or no branch)

secretory protein classification

tubular and acinus (acinus is berry like)

exocrine can secrete serous or mucous through __ secreation (__)

merocrine (exocytosis)

serous secreting glands:


-lumen surrounded by __


-__ nulceus


-secretory granules are __, even __, and near __


-has __

cell wedges


ROUND nucleus


dark, even e density, near apical


-has basal rER

mucous secreting glands:


-lumen with cell wedges


-nucleus is __ and located at __


-secretory granules are __, even __, located at __


-has a lot lighter of stain bc mucous hard to stain except with PAS it can be light pink stain the carbs

nucleus is flat and near BASAL


foamy, even e densities, located at APICAL